Effectiveness of Bioactive Compounds Against T47D Breast Ductal Carcinoma Cell Line: A Systematic Review
Authors
Riris Srikandi Mahardika , Fadilatul Rahmi Putri , Layla Azzahra , Rita Maliza , Kurniadi Ilham , Afif HamdaniDOI:
10.29303/jbt.v24i4.7067Published:
2024-10-07Issue:
Vol. 24 No. 4 (2024): Oktober - DesemberKeywords:
Anticancer, antioxidant, cytotoxic, breast cancer, secondary metabolite.Articles
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Abstract
Breast cancer is one of the highest causes of death from non-communicable diseases and is the second leading cause of death in the world after lung cancer. Cancer treatment causes bad side effects for the body, so researchers are currently looking for compounds with anticancer properties that come from plants. Plants contain secondary metabolites that act as antioxidants and anticancer, making them a potential source of cancer drugs. This article was written to determine the potential and content of various herbal plants as cell proliferation agents against breast cancer T474 cells. We collected articles from previous studies that had been conducted on this topic using the PubMed database in our review and selected twelve articles published in the last ten years with a period of 2014-2024. From the results obtained, it can be concluded that plants contain antioxidant compounds such as alkaloids and flavonoids which can act as anticancer agents and inhibit the growth of breast cancer.
References
Akram, M., Iqbal, M., Daniyal, M., Khan, A.U. (2017). Awareness and current knowledge of breast cancer. Biol Res, 50(1): 33. DOI: https://doi.org/10.1186/s40659-017-0140-9
Arunachalam, K. D., Arun, L. B., Annamalai, S. K., & Arunachalam, A. M. (2014). Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles. International Journal of Nanomedicine, 10: 31–41. https://doi.org/10.2147/IJN.S71182
Barkhordari, A., Jafari-Gharabaghlou, D., Turk, Z., & Zarghami, N. (2023). Potential anti-cancer effect of helenalin as a natural bioactive compound on the growth and telomerase gene expression in breast cancer cell line. Asian Pacific Journal of Cancer Prevention: APJCP, 24(1), 133. DOI: https://doi.org/10.31557/apjcp.2023.24.1.133
Basch, E., Ulbricht, C., Hammerness, P., Bevins, A., & Sollars, D. (2004). Thyme (Thymus vulgaris L.), Thymol. Journal Of Herbal Pharmacotherapy, 4(1), 49–67. https://doi.org/10.1080/J157v04n01_07
Bouskine, A., Nebout, M., Brücker-Davis, F., Benahmed, M., & Fenichel, P. (2009). Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor. Environmental health perspectives, 117(7), 1053–1058. DOI: https://doi.org/10.1289/ehp.0800367
Bús C, Kúsz N, Jakab G, Senobar Tahaei SA, Zupkó I, Endrész V, Bogdanov A, Burián K, Csupor-Löffler B, Hohmann J, & Andrea Vasas. (2018). Phenanthrenes from Juncus Compressus Jacq. with Promising Antiproliferative and Anti-HSV-2 Activities. Molecules, 23(8): 2085. DOI: https://doi.org/10.3390/molecules23082085
Bús C, Kúsz N, Kincses A, Szemerédi N, Spengler G, Bakacsy L, Purger D, Berkecz R, Hohmann J, Hunyadi A, et al. (2020). Antiproliferative Phenanthrenes from Juncus tenuis: Isolation and Diversity-Oriented Semisynthetic Modification. Molecules, 25(24):5983. DOI: https://doi.org/10.3390/molecules25245983
C. C. Krewer. (2012). Efeito in vivo e in vitro do Guarana nos disturbios metabolicos e nos biomarcadores inflamatorios associados a` lipotoxicidade [Ph.D. thesis]. DOI: http://repositorio.ufsm.br/handle/1/4451
Campos, M. M., Fernandes, E. S., Ferreira, J., Bortolanza, L. B., Santos, A. R., & Calixto, J. B. (2004). Pharmacological and neurochemical evidence for antidepressant-like effects of the herbal product Catuama. Pharmacology, biochemistry, and behavior, 78(4), 757–764. DOI: https://doi.org/10.1016/j.pbb.2004.05.024
Carvalho, L. V. D. N., Cordeiro, M. F., e Lins, T. U. L., Sampaio, M. C. P. D., de Mello, G. S. V., da Costa, V. D. C. M., ... & Rêgo, M. J. B. D. M. (2016). Evaluation of antibacterial, antineoplastic, and immunomodulatory activity of Paullinia cupana seeds crude extract and ethyl‐acetate fraction. Evidence‐Based Complementary and Alternative Medicine, 2016(1): 1203274. DOI: http://dx.doi.org/10.1155/2016/1203274
Chalertpet, K., Sangkheereeput, T., Somjit, P., Bankeeree, W., & Yanatatsaneejit, P. (2023). Effect of Smilax spp. and Phellinus linteus combination on cytotoxicity and cell proliferation of breast cancer cells. BMC Complementary Medicine and Therapies, 23(1): 177. DOI: https://doi.org/10.1186/s12906-023-04003-x
Chauhan A., Islam A., Prakash H, et al. (2021). Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions. J Pharm Anal, 2021. DOI: https://doi.org/10.1016/j.jpha.2021.07.002
Cherdshewasart, W., Traisup, V., & Picha, P. (2008). Determination of the estrogenic activity of wild phytoestrogen-rich Pueraria mirifica by MCF-7 proliferation assay. The Journal of reproduction and development, 54(1), 63–67. DOI: https://doi.org/10.1262/jrd.19002
Christy, A. O., Temitope, O. O., dan Bamidele, A. (2019). Antibacterial Activity, Chemical Compositions and Proximate Analysis of Ixora coccinea L. Leaves on Some Clinical Pathogens. International Journal of Current Research, 55-61. DOI: http://dx.doi.org/10.24941/ijcr.31856.08.2018
De Mattos-Arruda L, & Cortes J. (2012). Breast cancer and HSP90 inhibitors: is there a role beyond the HER2-positive subtype?. The Breast, 21 (4) :604-607. DOI: https://doi.org/10.1016/j.breast.2012.04.002
DeSantis, C.E., Bray, F., Ferlay, J., Lortet-Tieulent, J., Anderson, B.O., Jemal, A. (2015). International variation in female breast cancer incidence and mortality rates. Cancer Epidemiol Biomarkers Prev, 24(10): 1495–1506. DOI: https://doi.org/10.1158/1055-9965.epi-15-0535
Diab, K. A., Guru, S. K., Bhushan, S., & Saxena, A. K. (2015). In vitro anticancer activities of Anogeissus latifolia, Terminalia bellerica, Acacia catechu and Moringa oleiferna Indian plants. Asian Pacific Journal of Cancer Prevention, 16(15): 6423-6428. DOI: https://www.researchgate.net/publication/282650049
Drogosz J, Janecka A. (2019). Helenalin-a sesquiterpene lactone with multidirectional activity. Curr Drug Targets, 20, 444-52. DOI: https://doi.org/10.2174/1389450119666181012125230
Du, J., Singh, H. & Yi, TH. (2016). Antibacterial, anti-biofilm and anticancer potentials of green synthesized silver nanoparticles using benzoin gum (Styrax benzoin) extract. Bioprocess Biosyst Eng, 39: 1923–1931. DOI: https://doi.org/10.1007/s00449-016-1666-x
Durgo K, Koncar M, Komes D, Belscak C. A, Franekic J, Jakopovich I, Jakopovich N, Jakopovic B. (2013). Cytotoxicity of blended versus single medicinal mushroom extracts on human cancer cell lines: contribution of polyphenol and polysaccharide content. Int J Med Mushrooms, 15(5):435–48. DOI: https://doi.org/10.1615/IntJMedMushr.v15.i5.20
El-Shamy, A.I.; Abdel-Razek, A.F.; Nassar, M.I. (2015). Phytochemical review of Juncus L. genus (Fam. Juncaceae). Arab. J. Chem, 8, 614–623. DOI: https://doi.org/10.1016/j.arabjc.2012.07.007
Fadhilah, K., Wahyuono, S., & Astuti, P. (2020). A bioactive compound isolated from Duku (Lansium domesticum Corr) fruit peels exhibits cytotoxicity against T47D cell line. F1000Research, 9. DOI: https://doi.org/10.12688/f1000research.21072.1
Fila, C., Metz, C., & van der Sluijs, P. (2008). Juglone inactivates cysteine-rich proteins required for progression through mitosis. The Journal of biological chemistry, 283(31), 21714–21724. DOI: https://doi.org/10.1074/jbc.M710264200
Fox, E. M., Andrade, J., & Shupnik, M. A. (2009). Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways. Steroids, 74(7), 622–627. DOI: https://doi.org/10.1016/j.steroids.2008.10.014
Fujita M, Nakao Y, Matsunaga S, et al. (2001). Ancorinosides B–D, inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP), from the marine Sponge Penares sollasi Thiele. Tetrahedron, 57(7): 1229–1234. DOI: http://dx.doi.org/10.1016/S0040-4020(00)01128-5
Grigalius, I and Petrikaite, V. (2017). Relationships between antioxidant and anticancer activity of trihydroxyflavones. Molecules 22(12): 2169. DOI: https://doi.org/10.3390/molecules22122169
Hariono, M., Rollando, R., Karamoy, J., Hariyono, P., Atmono, M., Djohan, M., Wiwy, W., Nuwarda, R., Kurniawan, C., and Salin, N., et al. (2020). Bioguided fractionation of local plants against matrix metalloproteinase9 and its cytotoxicity against breast cancer cell models: In silico and in vitro study. Molecules, 2-17. DOI: https://doi.org/10.3390/molecules25204691
Hasibuan, P. A. Z., & Sumaiyah, S. (2019). The anti-proliferative and pro-apoptotic properties of ethanol Plectranthus amboinicus (Lour.) Spreng. leaves ethanolic extract nanoparticles on T47D cell lines. Asian Pacific journal of cancer prevention: APJCP, 20(3): 897. DOI: https://doi.org/10.31557%2FAPJCP.2019.20.3.897
Hasibuan, P.A.Z., Ilyas, S, & Nasution, M.P. (2013). Antioxidant activity of n-hexane, etylacetate and ethanolic extract of plectranthus amboinicus (Lour.) Spreng by DPPH and caroten - linoleic acid methods. Int J Pharmacy Teach Pract. 4: 755-8. DOI: https://doi.org/10.32734/idjpcr.v3i1.3323
Heidari, Z., Salehzadeh, A., Sadat Shandiz, S. A., & Tajdoost, S. (2018). Anti-cancer and anti-oxidant properties of ethanolic leaf extract of Thymus vulgaris and its bio-functionalized silver nanoparticles. 3 Biotech, 8: 1-14. DOI: https://doi.org/10.1007/s13205-018-1199-x
Hollingshead, M., Alley, M., Burger, A.M., Borgel, S., Pacula-cox, C., Fiebie, H.H., & Sausville, E.A. (2005). In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative. Cancer Chemother Pharmacol, 56: 115–125. DOI: https://doi.org/10.1007/s00280-004-0939-2
Hosseinzadeh S., A.J. Kukhdan, A.J., Hosseini, A., Armand, R. (2015). The application of Thymus vulgaris in traditional and modern medicine: a review. Global J. Pharmacol. 9: 260–266. DOI: 10.4236/ijcm.2015.69084
Hu, Y., Guo, D. H., Liu, P., Cao, J. J., Wang, Y. P., Yin, J., Zhu, Y., & Rahman, K. (2011). Bioactive components from the tea polyphenols influence on endogenous antioxidant defense system and modulate inflammatory cytokines after total-body irradiation in mice. Phytomedicine: international journal of phytotherapy and phytopharmacology, 18(11), 970–975. DOI: https://doi.org/10.1016/j.phymed.2011.02.012
Hyun J, Woo Y, Hwang D S, Jo G, Eom S, Lee Y, Park J C and Lim Y. (2010). Relationships between structures of hydroxyflavones and their antioxidative effects. Bioorganic and Medicinal Chemistry Letters, 20(18): 5510–5513. DOI: https://doi.org/10.1016/j.bmcl.2010.07.068
Jafari-Gharabaghlou D, Pilehvar-Soltanahmadi Y, Dadashpour M, et. al. (2018). Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells. Iran J Basic Med Sci, 21, 1167. DOI: https://doi.org/10.22038%2FIJBMS.2018.30460.7345
Jedeon, K., Loiodice, S., Marciano, C., Vinel, A., Canivenc Lavier, M. C., Berdal, A., & Babajko, S. (2014). Estrogen and bisphenol A affect male rat enamel formation and promote ameloblast proliferation. Endocrinology, 155(9), 3365–3375. DOI: https://doi.org/10.1210/en.2013-2161
Jeeno P, Tongban S, Yana P, Wongta A, Sutan K, Yadoung S, Hongsibsong S. (2022). Tentative Identifcation of Phytochemicals from Smilax glabra and Smilax corbularia Extracts by LC-QTOF/MS and Their Bioactive Potential Plants 11(16):2089. DOI: https://doi.org/10.3390/plants11162089
Ji, Y. B., Qu, Z. Y., & Zou, X. (2011). Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway. Experimental and toxicologic pathology: official journal of the Gesellschaft fur Toxikologische Pathologie, 63(1-2), 69–78. DOI: https://doi.org/10.1016/j.etp.2009.09.010
Juliawaty L.D., Ra’idah P.N., Abdurrahman S., Hermawati E., Alni A., Tan M I., Ishikawa, H., and Syah Y.M. (2020). 5, 6-Dihydro-α-pyrones from the leaves of Cryptocarya pulchinervia (Lauraceae). Journal of Natural Medicines, 23: 1–7. DOI: https://doi.org/10.1007/s11418-020-01397-7
Kashyap, D., Sharma, A., Tuli, H. S., Sak, K., Mukherjee, T., & Bishayee, A. (2018). Molecular targets of celastrol in cancer: Recent trends and advancements. Critical reviews in oncology/hematology, 128, 70–81. DOI: https://doi.org/10.1016/j.critrevonc.2018.05.019
Kataoka, J., Habuka, N., Furuno, M., Miyano, M., Takanami, Y., & Koiwai, A. (1991). DNA sequence of Mirabilis antiviral protein (MAP) a ribosome inactivating protein with and antiviral property from Mirabilis jalapa L. and its expression on Escherichia coli. J Biol Chem, 266(13): 8426-30. DOI: https://doi.org/10.1016/S0021-9258(18)92992-3
Kempisty B, Wojtanowicz-Markiewicz K, Ziolkowska A, Budna J, Ciesiolka S, Piotrowska H, Bryja A, Antosik P, Bukowska D, Wollenhaupt K. (2015). Association between progesterone and estradiol-17beta treatment and proteinexpression of pgr and PGRMC1 in porcine luminal epithelial cells: a real-time cell proliferation approach. J Biol Regul Homeost Agents 29: 39-50. DOI: https://europepmc.org/article/med/25864740
Kim, H. G., Cho, J. H., Jeong, E. Y., Lim, J. H., Lee, S. H., & Lee, H. S. (2006). Growth-inhibiting activity of active component isolated from Terminalia chebula fruits against intestinal bacteria. Journal of food protection, 69(9), 2205–2209. DOI: https://doi.org/10.4315/0362-028x-69.9.2205
Klein, T., Longhini, R., & de Mello, J. C. (2012). Development of an analytical method using reversed-phase HPLC-PDA for a semipurified extract of Paullinia cupana var. sorbilis (guaraná). Talanta, 88, 502–506. DOI: https://doi.org/10.1016/j.talanta.2011.11.023
Klungsupya, P., Suthepakul, N., Muangman, T., Rerk-Am, U., & Thongdon-A, J. (2015). Determination of Free Radical Scavenging, Antioxidative DNA Damage Activities and Phytochemical Components of Active Fractions from Lansium domesticum Corr. Fruit. Nutrients, 7(8), 6852–6873. DOI: https://doi.org/10.3390/nu7085312
Kriplani P, Guarve K, Baghel US (2020). Helenalin: An Anti-Inflammatory and Anti-Neoplastic Agent: A Review. CurrBioact Compd, 16, 1134-46. DOI: https://doi.org/10.2174/1573407216666191226121004
Kuete, V. (2017). Thymus vulgaris, in: V. Kuete (Eds.), Medicinal Spices and Vegetables from Africa, first ed. Elsevier Inc., pp. 599–609. ISBN: 978-0-12-809286-6. DOI: https://doi.org/10.1016/b978-0-12-809286-6.00028-5
Kurian JC, Mutatkar RK, Samraj E. (2003). Plants that heal. 1st ed. Pune, India: P.H. Lall, at and for the owners of Oriental Watchman Publishing House, Pune. 1:214-215. DOI: https://www.florajournal.com/archives/2020/vol8issue2/PartA/7-4-71-436.pdf
Kúsz, N., Stefkó, D., Barta, A., Kincses, A., Szemerédi, N., Spengler, G., ... & Vasas, A. (2021). Juncaceae species as promising sources of phenanthrenes: antiproliferative compounds from Juncus maritimus Lam. Molecules, 26(4): 999. DOI: https://doi.org/10.3390/molecules26040999
L. Majhenic, M. Skerget, and Z. Knez. (2007). Antioxidant and antimicrobial activity of guarana seed extracts. Food Chemistry, vol. 104, no. 3, pp. 1258–1268, DOI: https://doi.org/10.1016/j.foodchem.2007.01.074
Lakhdari, W.; Dehliz, A.; Acheuk, F.; Mlik, R.; Hammi, H.; Doumandji-Mitiche, B.; Gheriani, S.; Berrekbia, M.; Guermit, K.; Chergui, S. (2016). Ethnobotanical study of some plants used in traditional medicine in the region of Oued Righ (Algerian Sahara). J. Med. Plants Stud. 4, 204–211. DOI: http://dspace.ensa.dz:8080/jspui/handle/123456789/1871
Leal, A.A,. Terada, Y., Machado, M.P.S., (2001). Floral biology of a population of Mirabilis jalapa L. (Nyctaginaceae) from southern Brazil. Acta Scientiarum, 23(2): 587-91. DOI: https://pesquisa.bvsalud.org/portal/resource/pt/vti-725918?lang=en
Liu L, Li W, Koike K, Zhang S, Nikaido T. (2004). Newalpha-tetralonylglucosides from the fruit of Juglans mandshurica. Chem Pharm Bull Tokyo. 52:566–9. DOI: https://doi.org/10.1248/cpb.52.566
Lotha, R., & Sivasubramanian, A. (2018). Flavonoids nutraceuticals in prevention and treatment of cancer: a review. Asian J Ppharm Clin Res, 11, 42-7. DOI: https://doi.org/10.22159/ajpcr.2018.v11i1.23410
Lu C.L, Zhu W, Wang M, Xu X.J, Lu C.J. (2014). Antioxidant and anti-infammatory activities of phenolic-enriched extracts of Smilax glabra. Evid Based Complement Alternat Med. 910438. DOI: https://doi.org/10.1155/2014/910438
Manosroi, A., Jantrawut, P., Sainakham, M., Manosroi, W., & Manosroi, J. (2012). Anticancer activities of the extract from Longkong (Lansium domesticum) young fruits. Pharmaceutical biology, 50(11), 1397–1407. DOI: https://doi.org/10.3109/13880209.2012.682116
Martínez, M.L., Labuckas, D.O., Lamarque, A.L. and Maestri, D.M. (2010), Walnut (Juglans regia L.): genetic resources, chemistry, by-products. J. Sci. Food Agric., 90: 1959-1967. DOI: https://doi.org/10.1002/jsfa.4059
Matsumoto, T., Kitagawa, T., Teo, S., Anai, Y., Ikeda, R., Imahori, D., Ahmad, H. S. B., & Watanabe, T. (2018). Structures and Antimutagenic Effects of Onoceranoid-Type Triterpenoids from the Leaves of Lansium domesticum. Journal of natural products, 81(10), 2187–2194. DOI: https://doi.org/10.1021/acs.jnatprod.8b00341
Mellatyar, H., Talaei, S., & Nejati-Koshki, K. (2016). Targeting HSP90 gene expression with 17-DMAG nanoparticles in breast cancer cells. Asian Pacific Journal of Cancer Prevention, 17(5): 2453-2457. DOI: http://dx.doi.org/10.7314/APJCP.2016.17.5.2453
Miyano, M., Appelt K., Arita, M., Habuka, N., Kataoka, J., Ago,. H, Hideaki, T., Noma, M., Ashford, V., & Xuong, N. (1992). Crystallization and preliminary X-ray crystallographic analysis of Mirabilis antiviral protein. J Mol Biol, 226: 281-3. DOI: https://doi.org/10.1016/0022-2836(92)90142-7
Mouhajir, F., Hudson, J. B., Rejdali, M., & Towers, G. H. N. (2001). Multiple Antiviral Activities of Endemic Medicinal Plants Used by Berber Peoples of Morocco. Pharmaceutical Biology, 39(5), 364–374. DOI: https://doi.org/10.1076/phbi.39.5.364.5892
Natella, F., Nardini, M., Belelli, F., Pignatelli, P., Di Santo, S., Ghiselli, A., Violi, F., & Scaccini, C. (2008). Effect of coffee drinking on platelets: inhibition of aggregation and phenols incorporation. The British journal of nutrition, 100(6), 1276–1282. DOI: https://doi.org/10.1017/S0007114508981459
Nault J-C, Ningarhari M, Rebouissou S, et al (2019). The role of telomeres and telomerase in cirrhosis and liver cancer. Nat Rev Gastro Hepat, 16, 544-58. DOI: https://doi.org/10.1038/s41575-019-0165-3
Neri, I., Bianchi, F., Giacomini, F., & Patrizi, A. (2006). Acute irritant contact dermatitis due to Juglans regia. Contact dermatitis, 55(1), 62–63. DOI: https://doi.org/10.1111/j.0105-1873.2006.0847h.x
Ovais, M., Khalil, A. T., Raza, A., Khan, M. A., Ahmad, I., Islam, N. U., … Shinwari, Z. K. (2016). Green Synthesis of Silver Nanoparticles Via Plant Extracts: Beginning a New Era in Cancer Theranostics. Nanomedicine, 11(23): 3157–3177. https://doi.org/10.2217/nnm-2016-0279
Pan, T.-C.; Lo, C.-W.; Chong, W.M.; Tsai, C.-N.; Lee, K.-Y.; Chen, P.-Y.; Liao, J.-C.; Yu, M.-J. Monteoliva L, Albar JP. (2004). Differential proteomics: an overview of gel and non-gel based approaches. Brief Funct Genomic Proteomic. 3(3):220-39. DOI: https://doi.org/10.1093/bfgp/3.3.220.
Piao MJ, Kang KA, Lee IK, Kim HS, Kim S, Choi JY, Choi J, Hyun JW. (2011). Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis. Toxicol Lett, 201:92–100. DOI: https://doi.org/10.1016/j.toxlet.2010.12.010
Rajesh, E., Sankari, L. S., Malathi, L., & Krupaa, J. R. (2015). Naturally Occurring Products in Cancer Therapy. J Pharm Bioallied Sci, 7 (Suppl 1): S181–S183. DOI: https://doi.org/10.4103/0975-7406.155895
Ratnasari, J., Tan, M.I., Esyanti, R.R., and Juliawaty, L.D. (2023). Cryptobrachytone C from Cryptocarya pulchrinervia (Kosterm) Leaves on Proliferation, Apoptosis, Migration and Clonogenicity of MCF-7 and T47D Cell Lines. Tropical Life Sciences Research, 34(2):223–241. DOI: https://doi.org/10.21315/tlsr2023.34.2.11
Reis F.S, Barreira J.C, Calhelha R.C, Griensven L. J, Ćirić A, Glamočlija J, Soković M, Ferreira I. C. (2014). Chemical characterization of the medicinal mushroom Phellinus linteus (Berkeley & Curtis) Teng and contribution of diferent fractions to its bioactivity. LWT-Food Sci Technol, 58(2) : 478–8. https://doi.org/10.1016/j.lwt.2014.04.013
Ren, W., Qiao, Z., Wang, H., Zhu, L., Zhang, L. (2003). Flavonoids: Promising Anticancer Agents. Medicinal Research Review. 23(4): 519-534. DOI: https://doi.org/10.1002/med.10033
Rozina, R. (2016). Pharmacological and biological activities of Mirabilis jalapa L. Int J Pharmacol Res, 6(5): 160-8. DOI: 10.7439/ijpr.v7i3.4009
Rzeski, W., Stepulak, A., Szymański, M., Sifringer, M., Kaczor, J., Wejksza, K., Zdzisińska, B., & Kandefer-Szerszeń, M. (2006). Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells. Naunyn-Schmiedeberg's archives of pharmacology, 374(1), 11–20. DOI: https://doi.org/10.1007/s00210-006-0090-1
S. P. Bydlowski, R. L. Yunker, and M. T. R. Subbiah. (1988). A novel property of an aqueous guarana extract (Paullinia cupana): inhibition of platelet aggregation in vitro and in vivo. Brazilian Journal of Medical and Biological Research, vol. 21, no. 3, pp. 535– 538. DOI: https://europepmc.org/article/med/3228635
S.M. DebMandal. (2016). Thyme (Thymus vulgaris L.) oils. In: V. Preedy (Eds.). Essential Oils in Food Preservation, Flavor and Safety. Academic Press. pp. 825–834. ISBN: 9780124166417.
Sa’id,E. G. (2009). Review Of Agroindustrial Strategic Studies, Researches And Development In Indonesia: The Case Of Oil Palm, Cacao And Gambir. Jurnal Teknologi Industri Pertanian, 19(1). DOI: https://jurnalpenyuluhan.ipb.ac.id/index.php/jurnaltin/article/view/1109
Sahli R, Rivière C, Siah A, Smaoui A, Samaillie J, Hennebelle T, Roumy V, Ksouri R, Halama P, Sahpaz S. (2018). Biocontrol activity of effusol from the extremophile plant, Juncus maritimus, against the wheat pathogen Zymoseptoria tritici. Environ Sci Pollut Res Int, 25(30),29775-29783. DOI: https://doi.org/10.1007/s11356-017-9043-0
Sahuc, M. E., Sahli, R., Rivière, C., Pène, V., Lavie, M., Vandeputte, A., Brodin, P., Rosenberg, A. R., Dubuisson, J., Ksouri, R., Rouillé, Y., Sahpaz, S., & Séron, K. (2019). Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus, Is a New Inhibitor of Hepatitis C Virus RNA Replication. Journal of virology, 93(10), e02009-18. DOI: https://doi.org/10.1128/JVI.02009-18
Saini, V.K., Sewal, R.K., Ahmad, Y., Medhi, B. (2015). Prospective Observation Study of Adverse Drug Reactions of Anticancer Drug Used in Cancer Treatment in a Tertiary Care Hospital. 77:687-693 DOI: https://doi.org/10.4103/0250-474x.174990
Sadeghi Ekbatan S, Li XQ, Ghorbani M, Azadi B, Kubow S (2018) Chlorogenic acid and its microbial metabolites exert anti-proliferative effects, S-phase cell-cycle arrest and apoptosis in human colon cancer caco-2 cells. Int J Mol Sci 19:723. https://doi.org/10.3390/ijms19030723
Sandjo, L. P., & Kuete, V. (2013). Triterpenes and Steroids from the Medicinal Plants of Africa. Medicinal Plant Research in Africa,135–202. https://doi.org/10.1016/b978-0-12-405927-6.00004-7
Scherer, R and Godoy, H.T. (2009). Antioxidant activity index (AAI) by the 2, 2-diphenyl-1- picrylhydrazyl method. Food Chemistry 112(3): 654–658. DOI: https://doi.org/10.1016/j.foodchem.2008.06.026.
Schimpl, F. C., da Silva, J. F., Gonçalves, J. F., & Mazzafera, P. (2013). Guarana: revisiting a highly caffeinated plant from the Amazon. Journal of ethnopharmacology, 150(1), 14–31. DOI: https://doi.org/10.1016/j.jep.2013.08.023
Sharma, S. H., Thulasingam, S., & Nagarajan, S. (2017). Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. European journal of pharmacology, 795, 169–178. DOI: https://doi.org/10.1016/j.ejphar.2016.12.008
Shi ZN, Wang YD, Gong Y, Li FH, Zhu Y. (2019). New triterpenoid saponins with cytotoxic activities from Ligularia przewalskii. Phytochem Lett, 30, 215–219. DOI: https://doi.org/10.1016/j.phytol.2019.02.024.
Silva, L., Oriani, A. (2022). Ecological and evolutionary aspects of seed coat and seedling development in Juncus tenuis (Juncaceae, Poales), Plant Syst Evol. 308(31). DOI: https://doi.org/10.1007/s00606-022-01825-z
Smith, V., Sausville, E.A., Camalier, R.F., Fiebie, H.H., & Burger, A.H. (2005). Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. Cancer Chemother Pharmacol, 56: 126–137. DOI: https://doi.org/10.1007/s00280-004-0947-2
Stefkó, D., Kúsz, N., Csorba, A., Jakab, G., Bérdi, P., Zupkó, I., Hohmann, Judit & Vasas, A. (2019). Phenanthrenes from Juncus atratus with antiproliferative activity. Tetrahedron, 75(1): 116-120. DOI: https://doi.org/10.1016/j.tet.2018.11.039
Sun, J., Guo, Y., Fu, X., Wang, Y., Liu, Y., Huo, B., Sheng, J., & Hu, X. (2015). Dendrobium candidum inhibits MCF-7 cells proliferation by inducing cell cycle arrest at G2/M phase and regulating key biomarkers. OncoTargets and therapy, 9, 21–30. DOI: https://doi.org/10.2147/OTT.S93305
Sun, Y.S., Zhao, Z., Yang, Z.N., Xu ,F., Lu, H.J., Zhu, Z.Y., Shi, W., Jiang, J., Yao, P.P., Zhu, H.P. (2017). Risk Factors and Preventions of breast cancer. Int J Biol Sci, 13(11): 1387–1397. DOI: https://doi.org/10.7150/ijbs.21635
Syarifah, S., Widyawati, T., Anggraini, D. R., Wahyuni, A. S., & Sari, M. I. (2019). Anticancer activity of uncaria gambir roxb on T47D breast cancer cells. In Journal of Physics: Conference Series, 1317(1): 012106. DOI: https://iopscience.iop.org/article/10.1088/1742-6596/1317/1/012106/
Takanami, Y., Kuwata, S., Ikeda, T., & Kubo S. (1990). Purification and characterization of the anti-plant viral protein from Mirabilis jalapa L. Japanese Journal of Phytopathology, 56(4), 488-494. DOI: https://doi.org/10.3186/jjphytopath.56.488
Tantikanlayaporn, D., Robinson, L. J., Suksamrarn, A., Piyachaturawat, P., & Blair, H. C. (2013). A diarylheptanoid phytoestrogen from Curcuma comosa, 1,7-diphenyl-4,6-heptadien-3-ol, accelerates human osteoblast proliferation and differentiation. Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(8-9), 676–682. DOI: https://doi.org/10.1016/j.phymed.2013.02.008
Terra, X., Montagut, G., Bustos, M., Llopiz, N., Ardèvol, A., Bladé, C., Fernández-Larrea, J., Pujadas, G., Salvadó, J., Arola, L., & Blay, M. (2009). Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet. The Journal of nutritional biochemistry, 20(3), 210–218. DOI: https://doi.org/10.1016/j.jnutbio.2008.02.005
Tóth, Barbara., Liktor-Busa, E., Kúsz, N., Szappanos, Á ., Mándi, A., Kurtán, T., Urbán, E., Hohmann, J., Chang, F. R., and Vasas, A. (2016). Journal of Natural Products, 79 (11): 2814-2823. DOI: https://doi.org/10.1021/acs.jnatprod.6b00581
Tunjung, W.A.S and Sayekti, P.R.S. (2019). Apoptosis induction on human breast cancer T47D cell line by extracts of Ancorina sp. F100 Research, 8:168. DOI: https://doi.org/10.12688%2Ff1000research.17584.2
Wallacides, A., Chesnel, A., Ajj, H., Chillet, M., Flament, S., & Dumond, H. (2012). Estrogens promote proliferation of the seminoma-like TCam-2 cell line through a GPER-dependent ERα36 induction. Molecular and cellular endocrinology, 350(1), 61–71. DOI: https://doi.org/10.1016/j.mce.2011.11.021
Wang, X., Chen, Q., Huang, X., Zou, F., Fu, Z., Chen, Y., Li, Y., Wang, Z., & Liu, L. (2017). Effects of 17β-estradiol and tamoxifen on gastric cancer cell proliferation and apoptosis and ER-α36 expression. Oncology letters, 13(1), 57–62. DOI: https://doi.org/10.3892/ol.2016.5424
Wang, Y., Sun, J., Zhang, K., Hu, X., Sun, Y., Sheng, J., & Fu, X. (2018). Black tea and D. candidum extracts play estrogenic activity via estrogen receptor α-dependent signaling pathway. American Journal of Translational Research, 10(1): 114. DOI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801351/
Wardana, A. P., Aminah, N. S., Kristanti, A. N., Fahmi, M. Z., Zahrah, H. I., Widiyastuti, W., ... & Takaya, Y. (2023). Nano Uncaria gambir as Chemopreventive Agent Against Breast Cancer. International Journal of Nanomedicine, 4471-4484. DOI: https://doi.org/10.2147/IJN.S403385
Watthanachaiyingcharoen, R., Utthasin, P., Potaros, T., & Suppakpatana, P. (2010). Proteins from Mirabilis jalapa possess anticancer activity via an apoptotic pathway. J Health Res, 24(4), 161-165. DOI: https://www.thaiscience.info/Journals/Article/JHRE/10893320.pdf
Wicaksono, P. A., Martien, R., & Ismail, H. (2016). Formulation and cytotoxicity of ribosome-inactivating protein Mirabilis jalapa L. nanoparticles using alginate-low viscosity chitosan conjugated with anti-epcam antibodies in the T47D breast cancer cell line. Asian Pacific Journal of Cancer Prevention, 17(4): 2277-2284. DOI: http://dx.doi.org/10.7314/APJCP.2016.17.4.2277
Yadav, N., Ganie, S. A., Singh, B., Chhillar, A. K. and Yadav, S. S. (2019). Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L. Phytotherapy Research, 33(9):2163-2178. DOI: https://doi.org/10.1002/ptr.6405
Yamaguti-Sasaki, E., Ito, L. A., Canteli, V. C., Ushirobira, T. M., Ueda-Nakamura, T., Dias Filho, B. P., Nakamura, C. V., & de Mello, J. C. (2007). Antioxidant capacity and in vitro prevention of dental plaque formation by extracts and condensed tannins of Paullinia cupana. Molecules (Basel, Switzerland), 12(8), 1950–1963. DOI: https://doi.org/10.3390/12081950
Yeşilada, E. (2002). Biodiversity in Turkish Folk Medicine. In: Şener, B. (eds) Biodiversity. Springer, Boston, MA. DOI: https://doi.org/10.1007/978-1-4419-9242-0_14
Youssef, A.M.M., Maaty, D.A.M., and Al-Saraireh, Y. M. (2023). Phytochemical Analysis and Profiling of Antioxidants and Anticancer Compounds from Tephrosia purpurea (L.) subsp. apollinea Family Fabaceae. Molecules,28: 3939. DOI: https://doi.org/10.3390/molecules28093939
Yudhawan, I. S.E., & Puspitasari, I. (2020). Immunomodulatory Effect of Standardized Polysaccharide Fraction Syrup from Noni Fruit (Morinda Citrifolia) on Cytokines Level (IL-2 and IFN-γ) and Its Histological Evaluation in Rats Vaccinated with Hepatitis-B. Research Journal of Pharmacy and Technology, 13 (2), 882–888.
Yunarto, N., Elya, B., & Konadi, L. (2015). Potensi fraksi etil asetat ekstrak daun gambir (Uncaria gambir roxb.) sebagai antihiperlipidemia. Jurnal Kefarmasian Indonesia. 5(1): 1-10. DOI: http://www.jkefarind.com/index.php/jki/article/view/2959
Zeinoddini, S., Nabiuni, M., & Jalali, H. (2019). The synergistic cytotoxic effects of doxorubicin and Viola odorata extract on human breast cancer cell line T47-D. Journal of Cancer Research and Therapeutics, 15(5), 1073-1079. DOI: https://doi.org/10.4103/jcrt.jcrt_990_17
Zhang, X. B., Zou, C. L., Duan, Y. X., Wu, F., & Li, G. (2015). Activity guided isolation and modification of juglone from Juglans regia as potent cytotoxic agent against lung cancer cell lines. BMC Complementary and Alternative Medicine, 15(395): 1-8. DOI: https://doi.org/10.1186/s12906-015-0920-0
Zhao, M., Da-Wa, Z. M., Guo, D. L., Fang, D. M., Chen, X. Z., Xu, H. X., ... & Zhou, Y. (2016). Cytotoxic triterpenoid saponins from Clematis tangutica. Phytochemistry, 130, 228-237. DOI: https://doi.org/10.1016/j.phytochem.2016.05.009
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