Literature Review: The Effect of Preparation Methods on the Entrapment Efficiency of Herbal Extract Phytosomes

Aliza Salsabila Ramadhani; Windah Anugrah Subaidah

doi:10.29303/jbt.v25i3.9495

Literature Review: The Effect of Preparation Methods on the Entrapment Efficiency of Herbal Extract Phytosomes

Authors

Aliza Salsabila Ramadhani , Windah Anugrah Subaidah

DOI:

10.29303/jbt.v25i3.9495

Published:

2025-07-15

Issue:

Vol. 25 No. 3 (2025): Juli-September

Keywords:

Antisolvent precipitation, entrapment efficiency, herbal extract, phytosome, solvent evaporation, thin-layer hidration.

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Ramadhani, A. S., & Subaidah, W. A. (2025). Literature Review: The Effect of Preparation Methods on the Entrapment Efficiency of Herbal Extract Phytosomes. Jurnal Biologi Tropis, 25(3), 2892–2897. https://doi.org/10.29303/jbt.v25i3.9495

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Abstract

Improving the bioavailability of hydrophilic bioactive compounds in herbal medicines has become a key focus in pharmaceutical research, prompting interest in phytosome formulation strategies. This literature review examines how phytosome preparation methods influence entrapment efficiency (EE) to overcome this limitation. The study employed a literature review methodology, sourcing 13 peer-reviewed articles sourcing (2015–2025) from Google Scholar, PubMed, and Science Direct using keywords: phytosome, entrapment efficiency, herbal extract, thin-layer hydration, and antisolvent precipitation. Articles were selected based on inclusion criteria, namely studies discussing phytosome preparation methods, providing entrapment efficiency (EE) data, available in full-text format, published within the last 10 years, and written in either English or Indonesian. Analysis revealed that antisolvent precipitation consistently achieved high EE (>85%), while thin-layer hydration showed variable outcomes (14–99%) dependent on parameter optimization. Critical success factors included extract-phospholipid ratios (1:1–1:5), chemical interactions (hydrogen bonding), and temperature control (<60°C). This study concludes that optimized preparation methods significantly enhance phytosomal EE, recommending strict standardization of process parameters to advance herbal pharmaceutical development.

References

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Literature Review: The Effect of Preparation Methods on the Entrapment Efficiency of Herbal Extract Phytosomes

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