Antitumor from Several Plant Compounds Against Hepatocellular Carcinoma Cell Line Hep3B: Mini Systematic Review

Wardatul Aini; Azizah Amatu Zikrah; Sutri Wulansari Safril; Zozy Aneloi  Noni; Rita Maliza

doi:10.29303/jbt.v23i4.5528

Antitumor from Several Plant Compounds Against Hepatocellular Carcinoma Cell Line Hep3B: Mini Systematic Review

Authors

Wardatul Aini , Azizah Amatu Zikrah , Sutri Wulansari Safril , Zozy Aneloi Noni , Rita Maliza

DOI:

10.29303/jbt.v23i4.5528

Published:

2023-10-04

Issue:

Vol. 23 No. 4 (2023): October - December

Keywords:

Antitumor, hepatocellular carcinoma, Hep3B.

Articles

Downloads

How to Cite

Aini, W., Zikrah, A. A., Safril, S. W., Noni, Z. A. ., & Maliza, R. (2023). Antitumor from Several Plant Compounds Against Hepatocellular Carcinoma Cell Line Hep3B: Mini Systematic Review. Jurnal Biologi Tropis, 23(4), 449–457. https://doi.org/10.29303/jbt.v23i4.5528

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Liver cancer is a global health challenge, with more than one million cases expected by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cancer and accounts for approximately 90% of cases. Nature provides a large source of natural medicines and compounds, one of which is plants. So, this article is made to contain information on the potential of several plants as antitumor agents. The method of preparing articles through literature review studies that collect articles from various sources such as ScienceDirect, google scholar, PubMed and others in the range of 2013 to 2023. There are ten plant bioactive compounds that have been tested in vitro on Hep3B cell lines to see their toxicity. These plant bioactive compounds play an important role in the proliferation phase, cell cycle, and cell apoptosis in liver cancer and have potential as antitumor.

References

Asafo-Agyei KO, Samant H. Hepatocellular Carcinoma. [Updated 2023 Mar 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559177/

Bai, C., Zhao, J., Su, J., Chen, J., Cui, X., Sun, M. & Zhang, X. (2022). Curcumin induces mitochondrial apoptosis in human hepatoma cells through BCLAF1-mediated modulation of PI3K/AKT/GSK-3Β signaling [Preprint]. doi:10.21203/rs.3.rs-1493954/v1.

Giulitti, F., Petrungaro, S., Mandatori, S., Tomaipitinca, L., deFranchis, V., D’Amore, A., Filippini, A., Gaudio, E., Ziparo, E. & Giampietri, C. (2021). Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction. Front. Cell Dev. Biol, (9):629182. doi: 10.3389/fcell.2021.629182

Hsu, C., & Chung, G. (2012). Anticancer potential of emodin. BioMedicine, 2(3), 108-116. https://doi.org/10.1016/j.biomed.2012.03.003.

Isparnaning, I. Yanuar., Puspitasari, E. dan Pangaribowo, D. A. (2015). Uji Sitotoksisitas Ekstrak Etanol Daun Arcangelisia flava pada Sel Kanker Payudara MCF-7. Artikel Ilmiah Hasil Penelitian Mahasiswa.

Jain, D., Murti, Y., Khan, W. U., Hossain, R., Hossain, M. N., Agrawal, K. K., Ashraf, R. A., Islam, M. T., Janmeda, P., Taheri, Y., Alshehri, M. M., Daştan, S. D., Yeskaliyeva, B., Kipchakbayeva, A., Sharifi-Rad, J. & Cho, W. C. (2021). Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma. Oxid Med Cell Longev. 2021 Oct 31;2021:9068850. doi: 10.1155/2021/9068850. PMID: 34754365; PMCID: PMC8572616.

Jain, N., Kaushik, P., Pareek, A., Pareek, H. & Sharma, M. K. (2022). Plant-Based Bioactive Compounds in Cancer Therapeutics. In: Behera, K.K., Bist, R., Mohanty, S., Bhattacharya, M. (eds) Prebiotics, Probiotics and Nutraceuticals. Springer, Singapore. https://doi.org/10.1007/978-981-16-8990-1_3

Jiang, L., Wang, W., He, Q., Wu, Y., Lu, Z., Sun, J., Liu, Z., Shao, Y., & Wang, A. (2017). Oleic acid induces apoptosis and autophagy in the treatment of Tongue Squamous cell carcinomas. Scientific Reports, 7. https://doi.org/10.1038/s41598-017-11842-5.

Khan, H., Jia, W., Yu, Z., Zaib, T., Feng, J., Jiang, Y., Song, H., Bai, Y., Yang, B. & Feng, H. (2020) ‘Emodin succinyl ester inhibits malignant proliferation and migration of hepatocellular carcinoma by suppressing the interaction of AR and EZH2’, Biomedicine & Pharmacotherapy, 128, p. 110244. doi:10.1016/j.biopha.2020.110244.

Khan, H., Ni, Z., Feng, H., Xing, Y., Wu, X., Huang, D., Chen, L., Niu, Y. & Shi, G. (2021). Combination of curcumin with n-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncrna H19 to silence Wnt/β-catenin signaling. Phytomedicine, 91, 153706. https://doi.org/10.1016/j.phymed.2021.153706

Kim, S. Y., Park, C., Kim, M. Y., Ji, S. Y., Hwangbo, H., Lee, H., Hong, S. H., Han, M. H., Jeong, J., Kim, G., Son, C., Cheong, J. & Choi, Y. M. (2021). ROS-Mediated Anti-Tumor Effect of Coptidis Rhizoma against Human Hepatocellular Carcinoma Hep3B Cells and Xenografts. Int. J. Mol. Sci., (22): 4797. https://doi.org/10.3390/ijms22094797.

Llovet, J. M., Kelley, R. K., Villanueva, A. et al. (2021). Hepatocellular carcinoma. Nat Rev Dis Primerr, 7: 6. https://doi.org/10.1038/s41572-020-00240-3

Ma, C., Wei, Y., Liu, Q., Xin, Y., Cao, G. & Wang, X. (2019) ‘Polysaccharides from Hedyotis diffusa enhance the antitumor activities of cytokine-induced killer cells’, Biomedicine & Pharmacotherapy, 117, p. 109167. doi:10.1016/j.biopha.2019.109167.

Ma, J., Jin, Y., Zuo, H. X., Li, M. Y., Zhang, Z. H., Xing, Y., Wang, J. Y., Li, G., Piao, H., Gu, P. dan Jin, X. (2021). Anti-Tumor Effects of Carrimycin and Monomeric Isovalerylspiramycin I on Hepatocellular Carcinoma in Vitro and in Vivo. Frontiers in Pharmacology, (12):774231. doi: 10.3389/fphar.2021.774231.

Mazumder, K., Aktar, A., Roy, P., Biswas, B., Hossain, M. E., Sarkar, K. K., Bachar, S. C., Ahmed, F., Monjur-Al-Hossain, A. S. M. & Fukase, K. (2022). A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship. Molecules., 27(9):3036. doi: 10.3390/molecules27093036. PMID: 35566385; PMCID: PMC9102595.

McGlynn KA, Petrick JL, El-Serag HB. (2021). Epidemiology of hepatocellular carcinoma. Hepatology, 73(S1):4–13

Megger, D. A., Pott, L. L., Ahrens, M., Padden, J., Bracht, T., Kuhlmann, K., Eisenacher, M., Meyer, H. E., Sitek, B. (2013). Comparison of Label-free and Label-based Strategies for Proteome Analysis of Hepatoma Cell Lines. Biochimica et Biophysica Acta. https://doi.org/10.1016/j.bbapap.2013.07.017.

Mittal S, El-Serag HB, Sada YH, et al. (2016). Hepatocellular carcinoma in the absence of cirrhosis in United States veterans is associated with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol, 14(1):124–31.e1.

Möller, K., Zadeh, E. S., Görg, C., Dong, Y., Cui, X., Lim, A., Molo, C. Serra, C., Algíbez, A. M., Berzigotti, A., Piscaglia, F., Faiss, S., Dietrich, C. F. 2022. Focal liver lesions other than hepatocellular carcinoma in cirrhosis: Diagnostic challenges. Journal of Translational Internal Medicine, 10 (4). 10.2478/jtim-2022-0068.

Ojo OA, Adeyemo TR, Rotimi D, Batiha GE-S, Mostafa-Hedeab G, Iyobhebhe ME, Elebiyo TC, Atunwa B, Ojo AB, Lima CMG and Conte-Junior CA. (2022). Anticancer Properties of Curcumin Against Colorectal Cancer: A Review. Front. Oncol. 12:881641. doi: 10.3389/fonc.2022.881641

Wang N, Tan HY, Li L, Yuen MF, Feng Y. Berberine and Coptidis Rhizoma as potential anticancer agents: Recent updates and future perspectives. J Ethnopharmacol. 2015 Dec 24;176:35-48. doi: 10.1016/j.jep.2015.10.028. Epub 2015 Oct 19. PMID: 26494507.

Wu, P., Tseng, H., Chyau, C., Chen, J. & Chou, F. (2014). Piper Betle Leaf Extracts Induced Human Hepatocellular Carcinoma Hep3B Cell Death via MAPKs Regulating the p73 Pathway in Vitro and in Vivo. Food Funct, 5: 3320–3328. doi: 10.1039/c4fo00810cwww.rsc.org/foodfunction.

Yao, L., Yan, D., Jiang, B., Xue, Q., Chen, X., Huang, Q., Qi, L., Tang, D., Chen, X. & Liu, J. (2023) ‘Plumbagin is a novel GPX4 protein degrader that induces apoptosis in hepatocellular carcinoma cells’, Free Radical Biology and Medicine, 203, pp. 1–10. doi:10.1016/j.freeradbiomed.2023.03.263.

Yin, Z., Zhang, J., Chen, L., Guo, Q., Yang, B., Zhang, W., & Kang, W. (2020). Anticancer Effects and Mechanisms of Action of Plumbagin: Review of Research Advances. BioMed Research International, 2020. https://doi.org/10.1155/2020/6940953

Zhang, P., Wang, Q., Lin, Z., Yang, P., Dou, K. & Zhang, R. (2019). Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake. Onco Targets and Therapy, (12): 11751–11763. http://doi.org/10.2147/OTT.S235667.

Author Biographies

Zozy Aneloi Noni

Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Andalas, Universitas Andalas, Indonesia

Rita Maliza

Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Andalas, Universitas Andalas, Indonesia

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

Most read articles by the same author(s)

Rita Maliza, Hevi Horiza, Isolation and Identification of Gram Negative Bacteria in The Lumen Fluid of Colorectal Cancer Patients , Jurnal Biologi Tropis: Vol. 23 No. 4 (2023): October - December
Afdhal Raihan, Angga Kurnia Illahi, Siti Rokhimah, Tasya Putri Pratama Elisa, Rita Maliza, Identification of Bioactive Solutions of Corn Silk (Zea mays L.) Extract and Biological Activity Test By Bioinformatics , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Rilwan Efendi, Puti Khairunnajwa Amar, Resti Rahayu, Putra Santoso, Zozy Aneloi Noli, Rita Maliza, Organoid Culture Applications: Mini Systematic Review , Jurnal Biologi Tropis: Vol. 23 No. 4 (2023): October - December
Fadillah, Aulia Rahmi, Aldi Tamara Rahman, Nurul Annisa, Muhammad Hamdi Ibrahim, Rihadatul Aisyah, Reziq Marchellino Irwan, Rita Maliza, Effectiveness of Plant Bioactive Compounds as Colorectal Cancer Cell Line Inhibitors: A Systematic Review , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Elzam Naufal Zulfikri, Muhammad Hamdi Ibrahim, Tasya Putri Pratama Elisa, Dennisa Arra Nelvi, Kurniadi Ilham, Rita Maliza, Potential Bioactive Compounds of Plant as Anticancers in Lung Cancer A549 Cell Line: A Systematic Review , Jurnal Biologi Tropis: Vol. 24 No. 3 (2024): July - September
Riris Srikandi Mahardika, Fadilatul Rahmi Putri, Layla Azzahra, Rita Maliza, Kurniadi Ilham, Afif Hamdani, Effectiveness of Bioactive Compounds Against T47D Breast Ductal Carcinoma Cell Line: A Systematic Review , Jurnal Biologi Tropis: Vol. 24 No. 4 (2024): Oktober - Desember
Azizah Amatu Zikrah, Putra Santoso, Rita Maliza, Effects of Low Protein Diet on Body Weight and Hematological Parameters in Rats , Jurnal Biologi Tropis: Vol. 24 No. 3 (2024): July - September
Windi Nofri Yanti, Mifta Hulrahma, Kharisma Annisa Aprilia, Amelia Roza, Kurniadi Ilham, Rita Maliza, Systematic Review: Cytotoxicity Test of Bioactive Compounds of Asteraceae Family Plant Extracts on HeLa Cell Line , Jurnal Biologi Tropis: Vol. 24 No. 4 (2024): Oktober - Desember
Fadillah Fadillah, Reziq Marchellino Irwan , Muhamad Afif , Allimuddin Tofrizal , Elvina Zuhir, Rita Maliza, Effects of Glyphosate on Cognitive Development, Sensory Sensitivity and Locomotor Balance in Male Rats , Jurnal Biologi Tropis: Vol. 24 No. 3 (2024): July - September
Husna Fitri, Rizma Nurul Akhlas, Liana Fairuzannah Mahdiana, Rita Maliza, Effects of Arabika Coffee (Coffea arabica L.) Pulp Extracts on Anopheles sp. Larva Mortality , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue

1 2 > >>

Antitumor from Several Plant Compounds Against Hepatocellular Carcinoma Cell Line Hep3B: Mini Systematic Review

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

Author Biographies

Zozy Aneloi Noni

Rita Maliza

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow