Hepatic Alteration due to Formaldehyde Exposure on Wistar Rats (Rattus norvegicus)

Hidayat Makbul; Anak Agung Ayu Niti Wedayani; Abdul Qadar Punagi; Nova Audrey Luetta Pieter; Muhammad Husni Cangara; Ima Arum Lestarini; Novia Andansari Putri Restuningdyah

doi:10.29303/jbt.v24i1.6455

Hepatic Alteration due to Formaldehyde Exposure on Wistar Rats (Rattus norvegicus)

Authors

Hidayat Makbul , Anak Agung Ayu Niti Wedayani , Abdul Qadar Punagi , Nova Audrey Luetta Pieter , Muhammad Husni Cangara , Ima Arum Lestarini , Novia Andansari Putri Restuningdyah

DOI:

10.29303/jbt.v24i1.6455

Published:

2024-03-14

Issue:

Vol. 24 No. 1 (2024): Januari - Maret

Keywords:

Formaldehyde exposure, formaldehyde intoxication, hepatic alteration, hepatotoxicity, hepatomegaly, oxidative stress.

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Makbul, H., Wedayani, A. A. A. N., Punagi, A. Q., Pieter, N. A. L., Cangara, M. H., Lestarini, I. A., & Restuningdyah, N. A. P. (2024). Hepatic Alteration due to Formaldehyde Exposure on Wistar Rats (Rattus norvegicus). Jurnal Biologi Tropis, 24(1), 461–467. https://doi.org/10.29303/jbt.v24i1.6455

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Abstract

Formaldehyde is a hazardous chemical substance that can be found commonly in the environment which has various effects on cellular functions and could induce the cellular oxidative stress. Oxidative stress has a direct impact on the hepatic condition and could induce the activation of inflammatory mediators, lipid peroxidation, proteosomal degradation, and mitochondrial dysfunction resulting in hepatocyte injury that could be marked by hepatic enzyme elevation and hepatic weight alterations. This research was conducted using 16 Wistar rats (Rattus norvegicus), divided into 4 groups each containing 4 Wistar rats. The first group was the control group, while the other groups were exposed to formaldehyde 10% by inhalation at doses of 20, 30, and 40 ppm formaldehyde persistently for 6 hours daily for about 16 weeks. The result of this study reveals that formaldehyde induction has a significant impact on hepatic weight elevations (p=0.007) and ALT enzyme elevations (p=0.000) in the treatment groups compared with the control group. Collectively, our results provide valuable information on the hazardous effects of formaldehyde inhalation, especially on the liver.

References

Adetuyi, B. O., Okeowo, T. O., Adetuyi, O. A., Adebisi, O. A., Ogunlana, O. O., Oretade, O. J., Marraiki, N., Beshbishy, A. M., Welson, N. N., & Batiha, G. E. S. (2020). Ganoderma lucidum from red mushroom attenuates formaldehyde-induced liver damage in experimental male rat model. Biology, 9(10), 1–11. https://doi.org/10.3390/biology9100313

Caro-Maldonado, A., & Muoz-Pinedo, C. (2011). Dying for Something to Eat: How Cells Respond to Starvation. The Open Cell Signaling Journal, 3, 42–51. https://doi.org/10.2174/1876390101103010042

Driscoll, T. R., Carey, R. N., Peters, S., Glass, D. C., Benke, G., Reid, A., & Fritschi, L. (2015). The Australian Work Exposures Study: Prevalence of Occupational Exposure to Formaldehyde. Annals of Occupational Hygiene, 60(1), 132–138. https://doi.org/10.1093/annhyg/mev058

Kang, D. S., Kim, H. S., Jung, J. H., Lee, C. M., Ahn, Y. S., & Seo, Y. R. (2021). Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach. Genes and Environment, 43(1), 1–10. https://doi.org/10.1186/s41021-021-00183-5

IARC – INTERNATIONAL AGENCY FOR RESEARCH ON CANCER. Retrieved May 8, 2023, from Who.int website: https://www.iarc.who.int/

Kang, D. S., Lee, N., Shin, D. Y., Jang, Y. J., Lee, S. H., Lim, K. M., Ahn, Y. S., Lee, C. M., & Seo, Y. R. (2022). Network-based integrated analysis for toxic effects of high-concentration formaldehyde inhalation exposure through the toxicogenomic approach. Scientific Reports, 12(1), 1–12. https://doi.org/10.1038/s41598-022-09673-0

Kim, C.-S., Park, S., & Kim, J. (2017). The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise. Journal of Exercise Nutrition & Biochemistry, 21(3), 55–61. https://doi.org/10.20463/jenb.2017.0027

Kwo, P. Y., Cohen, S. M., & Lim, J. K. (2017). ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries. American Journal of Gastroenterology, 112(1), 18–35. https://doi.org/10.1038/ajg.2016.517

M, A., T, A., R, K., & MR, I. (2016). Effects of formaldehyde intoxication on liver of Swiss albino mice. IOSR Journal of Agriculture and Veterinary Science, 09(09), 76–81. https://doi.org/10.9790/2380-0909027681

Mahjoub, S., & Roudsari, J. M. (2012). Role of oxidative stress in pathogenesis of metabolic syndrome. Caspian Journal of Internal Medicine, 3(1), 386–396.

Susilawati, N. K., Yasa, I. W. P. S., Suardana, W., Maliawan, S., Jawi, I. M., Romdhoni, A. C., Kadriyan, H., Putra, I. W. G. A. E., & Arijana, I. G. K. N. (2022). Purple Sweet Potato Reduces Malondialdehyde and TNF-a, Increases p53, and Protects Histopathological Appearance in Formaldehyde-induced Nasopharyngeal Carcinoma Rats. Indonesian Biomedical Journal, 14(2), 211–217. https://doi.org/10.18585/inabj.v14i2.1906

Tesfaye, S., Hamba, N., Gerbi, A., & Negeri, Z. (2021). Occupational formaldehyde exposure linked to increased systemic health impairments and counteracting beneficial effects of selected antioxidants. Alexandria Journal of Medicine, 57(1), 157–167. https://doi.org/10.1080/20905068.2021.1926172

Tulpule, K., & Dringen, R. (2013). Formaldehyde in brain: An overlooked player in neurodegeneration? Journal of Neurochemistry, 127(1), 7–21. https://doi.org/10.1111/jnc.12356

W.E. Olooto. (2010). Assessment of The Effect of Formaldehyde Exposure on The Liver in Mortuaty Workers in South Western Nigeria. 57(4). https://doi.org/10.4314/nmp.v57i4.57942

Xu, M., Tang, H., Rong, Q., Zhang, Y., Li, Y., Zhao, L., Ye, G., Shi, F., & Lv, C. (2017). The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats. BioMed Research International, 2017. https://doi.org/10.1155/2017/6525474

Zhang, Q., Tian, P., Zhai, M., Lei, X., Yang, Z., Liu, Y., Liu, M., Huang, H., Zhang, X., Yang, X., Zhao, Y., & Meng, Z. (2018). Formaldehyde regulates vascular tensions through nitric oxide-cGMP signaling pathway and ion channels. Chemosphere, 193, 60–73. https://doi.org/10.1016/j.chemosphere.2017.11.013

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Hepatic Alteration due to Formaldehyde Exposure on Wistar Rats (Rattus norvegicus)

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