Pathophysiology of Rabies Encephalitis and Treatment of Rabies : A Literature Review

Gintis Dhimar Ginuluh; Alya Syafa Kamila; Anang Muh Naufal Humam; Putri Fatimah Helmiana; Rukmanggana Satya Pratiwi; Ilsa Hunaifi; Lazuardi Arsy

doi:10.29303/jbt.v24i1b.7951

Pathophysiology of Rabies Encephalitis and Treatment of Rabies : A Literature Review

Authors

Gintis Dhimar Ginuluh , Alya Syafa Kamila , Anang Muh Naufal Humam , Putri Fatimah Helmiana , Rukmanggana Satya Pratiwi , Ilsa Hunaifi , Lazuardi Arsy

DOI:

10.29303/jbt.v24i1b.7951

Published:

2024-12-10

Issue:

Vol. 24 No. 1b (2024): Special Issue

Keywords:

Clinical manifestation, rabies encephalitis, patophysiology, treatment.

Articles

Downloads

pdf

How to Cite

Ginuluh, G. D., Kamila, A. S., Humam, A. M. N., Helmiana, P. F., Pratiwi, R. S., Hunaifi, I., & Arsy, L. (2024). Pathophysiology of Rabies Encephalitis and Treatment of Rabies : A Literature Review. Jurnal Biologi Tropis, 24(1b), 85–92. https://doi.org/10.29303/jbt.v24i1b.7951

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Rabies is a zoonotic disease transmitted by the saliva of mammals infected with Rabies lyssavirus. Rabies is a lethal disease that is still a health problem in Indonesia. This article aims to review the clinical features, diagnosis, pathophysiology, and management of rabies. This research collects and analyzes literature related to rabies that was conducted through Google Scholar, Pubmed, and ScienceDirect. The review results show that rabies with clinical features, especially rabies encephalitis had poor outcomes. Rabies is a neurotropic virus that spreads through neurons and attack CNS causing rabies encephalitis. The management is categorized into pre-exposure treatment, post-exposure treatment, and palliative treatment. An understandable information regarding the mechanism of rabies encephalitis and rabies management is very important to minimize deaths caused by rabies.

References

Ambarwaty, M., Nara, M. B., & Theodorus, D. (2023). Manajemen Infeksi Rabies Berisiko Tinggi: Studi Kasus Tanpa Serum Anti-Rabies. Jurnal Kedokteran dan Kesehatan: Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 10(3), 293-300. https://doi.org/10.32539/JKK.V10I3.21898.

Ashwini, M.A., Pattanaik, P. and Mani, R.S. (2024) ‘Recent updates on laboratory diagnosis of rabies’, Indian Journal of Medical Research, pp. 48–61. Available at: https://doi.org/10.4103/ijmr.IJMR.

Bintang, A.K. et al. (2023) ‘Rabies : Diagnostic , Treatment , and Prevention’, 8(2), pp. 1–13.

Boushab, B.M. et al. (2022) ‘Diagnosis and management of rabies encephalitis in two patients in northwest Africa: A case series’, Clinical Case Reports, 10(11), pp. 1–4. Available at: https://doi.org/10.1002/ccr3.6530.

CDC (2023) Travel-Associated Infections & Diseases: Rabies. 2024th edn. Oxford University Press.

Farihah, I.H. et al. (2022) ‘Neuropathogenesis of Human Rabies’, KESANS : International Journal of Health and Science, 1(4), pp. 376–386. Available at: https://doi.org/10.54543/kesans.v1i4.37.

Gelolodo, M.A. et al. (2023) ‘Review: Rabies Virus (Rabv) Dan Patogenesisnya’, Partner, 28(2), p. 177. Available at: https://doi.org/10.35726/jp.v28i2.7104.

Hemachudha, P. and Hemachudha, T. (2021) ‘Rabies: Presentation, case management and therapy’, Journal of the Neurological Sciences, 424(August 2020), p. 117413. Available at: https://doi.org/10.1016/j.jns.2021.117413.

Imelda, Y.M. and Sudewi, A.A.R. (2015) ‘Patogenesis Rabies – Aspek Neurotransmiter’, Continuing Medical Education, 42(2), pp. 87–91. Available at: https://doi.org/10.55175/cdk.v42i2.1035.

Jane Ling, M.Y. et al. (2023) ‘Rabies in Southeast Asia: A systematic review of its incidence, risk factors and mortality’, BMJ Open, 13(5), pp. 1–8. Available at: https://doi.org/10.1136/bmjopen-2022-066587.

Kemenkes (2019) Buku Saku Rabies Petunjuk Teknis Penatalaksanaan Kasus Gigitan Hewan Penular Rabies Di Indonesia, Dirjen P2P. Jakarta. Available at: https://ayosehat.kemenkes.go.id/media-buku-saku-rabies--petunjuk-teknis-penatalaksanaan-kasus-gigitan-hewan-penular-rabies-di-indonesia.

Lacy, M. et al. (2024) ‘Human Rabies Rabies Treatment — From Treatment — From Palliation Palliation to’, Viruses, 16, p. 160. Available at: https://doi.org/doi: 10.3390/v16010160.

Liu, C. and Cahill, J.D. (2020) ‘Epidemiology of Rabies and Current US Vaccine Guidelines.’, Rhode Island medical journal (2013), 103(6), pp. 51–53. Available at: http://www.ncbi.nlm.nih.gov/pubmed/32752569.

Nadal, D. et al. (2023) ‘Rabies post-exposure prophylaxis delivery to ensure treatment efficacy and increase compliance’, IJID One Health, 1, p. 100006. Available at: https://doi.org/10.1016/j.ijidoh.2023.100006.

Riccardi, N. et al. (2021) ‘Rabies in Europe: An epidemiological and clinical update’, European Journal of Internal Medicine, 88(March), pp. 15–20. Available at: https://doi.org/10.1016/j.ejim.2021.04.010.

Scott, T.P. and Nel, L.H. (2021) ‘Lyssaviruses and the Fatal Encephalitic Disease Rabies’, Frontiers in Immunology, 12(December), pp. 1–7. Available at: https://doi.org/10.3389/fimmu.2021.786953.

Soler-Rangel, S. et al. (2020) ‘Rabies encephalitis and extra-neural manifestations in a patient bitten by a domestic cat’, Revista do Instituto de Medicina Tropical de Sao Paulo, 62(June 2019), pp. 1–5. Available at: https://doi.org/10.1590/s1678-9946202062001.

Tajmalzai, A. and Zarabi, A. (2024) ‘Magnetic resonance imaging in rabies encephalitis, a case report, and review of the literature’, Radiology Case Reports, 19(7), pp. 2644–2649. Available at: https://doi.org/10.1016/j.radcr.2024.03.072.

WHO. (2018). Rabies vaccines and immunoglobulins: WHO position April 2018’.

Wilson, P.J. (2020) Clinical Signs and Symptoms of Rabies, Rabies. Elsevier Inc. Available at: https://doi.org/10.1016/b978-0-323-63979-8.00002-7.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

Pathophysiology of Rabies Encephalitis and Treatment of Rabies : A Literature Review

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow