Antifungal activity test of nanosilver combination with lip balm cosmetic preparation
DOI:
10.29303/jpm.v18i5.5601Published:
2023-09-30Issue:
Vol. 18 No. 5 (2023): September 2023Keywords:
Silver Nanoparticles, Antifungal Activity, Lip Balm, UV-Vis Spectrophotometer, TEMArticles
Downloads
How to Cite
Downloads
Metrics
Abstract
Nanosilveris is a silver-based material with nanometer particle sizes (1-100 nm) predicted to be antifungal or an alternative to preservatives in lip balm preparations that are biocompatible. The nanosilver synthesis process in this study used the bottom-up method by adding sodium citrate as a reducing agent and stabilizer. This study aimed to determine the characteristics of the results of 20 ppm nanosilver synthesis using a UV-Vis and TEM spectrophotometer and to determine the antifungal activity of nanosilver in lip balm cosmetic preparations. Variations in adding 20 ppm nanosilver into lip balm preparations are 5%, 10%, and 15%. The results of characterization using a UV-Vis spectrophotometer, namely 20 ppm nanosilver, were quite stable in storage for 2 months, and the results of characterization using TEM also showed that the formed nanosilver remained stable with a nanometer size range ranging from 11.42 nm to 43.95 nm. The antifungal activity test was carried out using the Direct Microscopic Count (DMC) method by counting directly under a microscope. Based on the data obtained, it shows that the antifungal activity of the combination of nanosilver and lip balm preparations is almost equivalent to the antifungal activity of parabens. It has produced lip balm preparations with nanosilver. This is indicated by the value of the inhibition rate (%). The inhibition of fungal growth produced by lip balm preparations with parabens is almost the same as the inhibition rate (%) produced by lip balm preparations with nanosilver. The inhibition rate of lip balm preparations with parabens was 89.11%. In comparison, the inhibition rate of lip balm preparations with a nanosilver concentration of 15% was 82.31%, so it can be concluded that nanosilver has good antifungal activity and is biocompatible so that nanosilver can be used as an alternative to paraben preservatives.
References
Kadu, M., Vishwasrao, S., & Singh, S. (2015). Review Article on Natural Lip Balm—International Journal of Research in Cosmetic Science.
Budecka, A., & Kunicka-Styczyńska, A. (2014). Microbiological contaminants in cosmetics - isolation and characterization. Biotechnology and Food Sciences Research Article Biotechnol Food Sci, 78(1), 15–23.
Taufikurohmah, T., & Rusmini. (2016). Kimia kosmetik. Jurusan Kimia Universitas Negeri Surabaya.
Novita, & Ade Maria Ulfa. (2017). Penetapan Kadar Nipagin Pada Sediaan Pelembab Wajah Secara Kromatografi Lapis Tipis Dan Spektofotometri Uv. Jurnal Analisis Farmasi, 2(3), 181–187.
BPOM. (2011). Persyaratan Teknis Badan Kosmetik, Keputusan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia. BPOM RI.
Susanti, H. E., Ulfa, A. M., & Purnama, R. C. (2018). Penetapan Kadar Nipagin (Methylparaben) Pada Sabun Mandi Cair Secara Spektofotometri Uv-Vis. In Jurnal Farmasi Malahayati (Vol. 1, Issue 1, pp. 31–36).
Tjiang, W. M., Diah, N. P., Dewi, K., Agus, P., Prayoga, A., Putu, D., Suariyani, A., Kopang Maharani, G. A., Rismayani, P. A., Made, N., & Astuti, W. (2019). Analisis Kualitatif Dan Kuantitatif Kandungan Paraben Dalam Kosmetik Hand Body Lotion. Indonesian Journal of Legal and Forensic Sciences, 9(2), 89–96.
Latarissa, I. R., & Husni, P. (2018). Aplikasi Teknologi Nanopartikel pada Sediaan Kosmetik. Farmaka, 14(1), 104–113.
Apriliani, N. F., & Aniriani, G. W. (2017). Analisis Uji Mikrobiologi dan Logam Berat pada Scrub Berbahan Dasar Kapur Sirih. Jurnal Ilmiah Sains. 17(2). 126-130.
Dwandaru, W. S. B., Putri, C. Z. M., & Yulianti, E. (2016). Pengaruh variasi konsentrasi bahan aditif laruutan nanopartikel perak terhadap seifat anti-jamur cat dinding sebagai aplikasi teknologi nano dalam industri cat dinding. In Inotek (Vol. 20, pp. 1–18). http://edupaint.com
Imaningsih, W., Junaidi, A. B., & Kurniawan, I. (2020). Uji potensi antifungi koloid perak nanopartikel (AgNPs) terhadap Aspergillus niger. Bioscientiae, 17(1), 25–39.
Adelia Jalestri, D., & Titik Taufikurohmah. (2016). Uji Aktivitas Antifungi Nanosilver Dalam Krim Pagi Terhadap Fungi Candida albicans. UNESA Journal of Chemistry, VII(28).
Isnaeni, I. W., Mahmudi, & Rifada, A. (2020). Studi Kelayakan dan Keamanan Penggunaan Nanogold Sebagai Bahan Baku Produk Kosmetik. Lembaga Ilmu Pengetahuan Indonesia, Kawasan Puspiptek.
(SCCS), S. C. on C. S. (2018). Colloidal Silver (nano). http://ec.europa.eu/health/scientific_committees/experts/declarations/sccs_en.htm
Zou, Y., Zhao, L., Zhou, Y., Huang, Y., & Liu, D. (2018). The Effects of Nanosilver-Containing Lip Balm on Lip Skin Moisturization. Journal of Cosmetic Science, 36(2).
WHO (2003). Silver in Drinking Water. Journal of Guidelines for Drinking-Water Quality, 2nd, 2.
Setiari, N. M. N., Ristiati, N. P., & Warpala, I. W. S. (2019). Aktivitas Antifungi Kombinasi Ekstrak Daun Sirih (Piper betle) dan Ekstrak Kulit Buah Jeruk (Citrus reticulata) untuk Menghambat Pertumbuhan Candida albicans. In Jurnal Pendidikan Biologi Undiksha (Vol. 6, Issue 2, pp. 72–82).
Cahyanti, A. D. (2022). Production and Organoleptic Test of Body Sanitizer Nanogold, Nanosilver, and Eucalyptus Oil in the Pandemic Covid 19. International Journal of Current Science Research and Review, 05(04), 1861–1870.
Taufikurohmah, T., & Tantyani, T. A. (2020). Antibacterial and Antifungal Activity of Silver Nanoparticles Against Neisseria Gonorrhoeae and Candida Albicans. International Journal of Research -GRANTHAALAYAH, 8(6), 179–187.
Li, L., Pan, H., Deng, L., Qian, G., Wang, Z., Li, W., & Zhong, C. (2022). The antifungal activity and mechanism of silver nanoparticles against four pathogens causing kiwifruit post-harvest rot. In Frontiers in Microbiology (Vol. 13, pp. 1–16).
Erwiyani, A. R., Destiani, D., & Kabelen, S. A. (2018). Pengaruh Lama Penyimpanan Terhadap Sediaan Fisik Krim Daun Alpukat (Persea Americana Mill) dan daun sirih hijau (Piper betle Linn). Indonesian Journal of Pharmacy and Natural Product, 1(1).
Fauziah, A. (2021). Formulasi dan Evaluasi Fisik Sediaan Lip Balm dari Kulit Papaya. Skripsi. Politeknik Harapan Bersama.
Nurcahyo, R. Y., & Wibawa, P. J. (2022). Fabrikasi Ramah Lingkungan Komposit Nano Karbon Aktif-Partikel Perak dan Uji Aktifitas Antibakterinya. Greensphere: Journal of Environmental Chemistry, 2(1), 31–37.
Arfi, K., & Taufikurohmah, T. (2017). Pemanfaatan Nanosilver Sebagai Antibakteri dalam Sediaan Farmasi Krim Pelembab Mata. UNESA Journal of Chemistry, 6(1), 11–19.
Alharbi, N. S., Alsubhi, N. S., & Felimban, A. I. (2022). Green synthesis of silver nanoparticles using medicinal plants: Characterization and application. Journal of Radiation Research and Applied Sciences, 15(3), 109–124.
Aritonang, H. F., Katja, D. G., & Lolo, W. A. (2022). Biosintesis Nanopartikel Perak (Ag) Menggunakan Ekstrak Daun Afrika (Vernonia Amygdalina) Dan Polietilen Glikol 6000 Serta Aplikasinya Sebagai Detektor Ion Logam Berat. Universitas Sam Ratulangi Manado.
Anggraini, F. N. A. (2018). Validasi Metode Analisis Melamin Menggunakan Nanopartikel Perak (NPP) Hasil Bioreduksi Ekstrak Buah Kersen (Muntingia calabura L.). Jurusan Farmasi UIN Malang.
Apriandanu, D., Wahyuni, S., & Hadisaputro, S. (2013). Sintesis Nanopartikel Perak Menggunakan Metode Poliol Dengan Agen Stabilisator Polivinilalkohol (PVA). Jurnal MIPA, 36(2), 157–168.
Inawati, R., S., & Juliana, M. (2021). Formulasi dan Evaluasi Sediaan Lip Balm Ekstrak Kayu Secang (Cesalpinia sappan L Sebagai Pewarna Alami. In Sekolah Tinggi Teknologi Industri dan Farmasi Bogor. Sekolah Tinggi Teknologi Industri dan Farmasi Bogor.
Bella Mega Silvia, & Mentari Luthfika Dewi. (2022). Studi Literatur Pengaruh Jenis dan Konsentrasi Basis terhadap Karakteristik Masker Gel Peel Off. Jurnal Riset Farmasi, 2(1), 30–38.
Jabal, C., 1, R., Pujiyanto, S., & Rukmi, I. (2021). Analisis Mikrobiologis Produk Lipstik Cair yang Digunakan oleh Penata Rias. Journal of Biology and Applied Biology, 4(2), 105–114.
Aidina, S. (2020). Formula dan Aktivitas Antioksidan Sediaan Lip Balm yang Diperkaya Ekstrak Daun Bidara ( Ziziphus spina-christi L .) Skripsi 2020 M / 1441 H. Program Studi Kimia Fakultas Sains dan Teknologi Universitas Islam Negeri Syarif Hidayatullah Jakarta.
Nst, R. A. (2022). Uji Fisikokimia Pada Sediaan Lip balm Dari Minyak Pala (Myristica fragrans Houtt) (pp. 1–60).
Author Biographies
Elys Safitri, Universitas Negeri Surabaya
Titik Taufikurohmah, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya
License
Copyright (c) 2023 Elys Safitri, Titik Taufikurohmah
This work is licensed under a Creative Commons Attribution 4.0 International License.
The following terms apply to authors who publish in this journal:
1. Authors retain copyright and grant the journal first publication rights, with the work simultaneously licensed under a Creative Commons Attribution License 4.0 International License (CC-BY License) that allows others to share the work with an acknowledgment of the work's authorship and first publication in this journal.
2. Authors may enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., posting it to an institutional repository or publishing it in a book), acknowledging its initial publication in this journal.
3. Before and during the submission process, authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website), as this can lead to productive exchanges as well as earlier and greater citation of published work (See The Effect of Open Access).
