Application of Simplex Lattice Design Method on The Optimisation of Deodorant Roll-on Formula of Ashitaba (Angelica keiskei)

Wahida Hajrin; Windah Anugrah Subaidah; Yohanes Juliantoni; Dyke Gita Wirasisya

doi:10.29303/jbt.v21i2.2717

Application of Simplex Lattice Design Method on The Optimisation of Deodorant Roll-on Formula of Ashitaba (Angelica keiskei)

Authors

Wahida Hajrin , Windah Anugrah Subaidah , Yohanes Juliantoni , Dyke Gita Wirasisya

DOI:

10.29303/jbt.v21i2.2717

Published:

2021-07-06

Issue:

Vol. 21 No. 2 (2021): Mei - Agustus

Keywords:

Ashitaba, Angelica keiskei, deodorant roll-on, optimization, simplex lattice design

Articles

Downloads

How to Cite

Hajrin, W., Subaidah, W. A., Juliantoni, Y., & Wirasisya, D. G. (2021). Application of Simplex Lattice Design Method on The Optimisation of Deodorant Roll-on Formula of Ashitaba (Angelica keiskei). Jurnal Biologi Tropis, 21(2), 501–509. https://doi.org/10.29303/jbt.v21i2.2717

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Ashitaba is known to have antioxidant activity and gram-positive antibacterial activity that causes body odor. This is the potential activity for an active substance to be developed as deodorant. The appropriate formula is needed, so it is necessary to optimize the formula using the right method. This study aimed was to determine the application of the simplex lattice design method on the optimization of a deodorant roll-on formula of ashitaba extract. Ashitaba was extracted by the maceration method. The formula optimization design was determined using the simplex lattice design method by Design ExpertÃÂ®7.5.1. The components for optimization were the concentration of carbopol and concentration of TEA, and the optimization parameters were the spreadability test, sticky power, and pH test. The optimum formula of deodorant consists of 0.45% carbopol and 2.05% TEA. The responses of optimum formula obtained spreadability test 6.32 ÃÂ± 0.33 cm, sticky power 44.67 ÃÂ± 3.94 seconds, and pH 7.73 ÃÂ± 0.17. These results meet the criteria for good preparation but need further testing related to the effectiveness of the preparation and the level of acceptance of the preparation by the user.

References

Anggasta, WG (2016). Optimasi formula gel ekstrak etanolik daun sirih merah (Piper crocatum Ruiz. & Pav.) dengan kombinasi basis karbomer dan CMC-Na menggunakan metode simplex lattice design. Skripsi. Universitas Gadjah Mada, Yogyakarta.

Enoki, T., Ohnogi, H., Nagamine, K., Kudo, Y., Sugiyama, K., Tanabe, M., Kobayashi, E., Sagawa, H. ... Kato, I., (2007). Antidiabetic activities of chalchones isolated from Japanese herbs, angelica keiskei. Journal of Agriculture and Food Chemistry, 55(16): 6013-6017.

Garg A, Aggarwal D, Garg S, & Singla AK (2002). Spreading of semiÃÂ¬solid formulations an update. Pharmaceutical Technology, 26: 84-105.

Hadinugroho, W. & Fudholi, A. (2011). Optimasi formula tablet lepas lambat ibuprofen secara simplex lattice design dengan campuran carrageenan, kalsium sulfat, dan PVP-K30. Majalah Farmasi Indonesia, 22(4): 300-305.

Harim, EA (2013). Optimasi komposisi pelarut ekstraksi buah mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) dengan parameter kadar flavonoid total secara simpelx lattice design. Skripsi. Universitas Sebelas Maret, Surakarta.

Inamori, Y., Baba, K., Tsujibo, H., Taniguchi, M., Nakata, K., & Kozawa, M. (1991). Antibacterial activity of two chalchones, xanthoangelol and 4-hydroxyderricin, isolated from the root of angelica keiskei koidzumi. Chem. Pharm. Bull., 39(6): 1604Ã¢â¬â1605.

Juliantoni, Y. (2014). Optimasi formula sirup ekstrak etanolik daun kembang sepatu (Hibiscus rosa-sinensis L.) dengan bahan tambahan gliserin, sirupus simplex, dan CMC-Na. Skripsi. Universitas Gadjah Mada, Yogyakarta.

Kholisatunnisa, H. (2017). Optimasi formulasi salep ekstrak etanol daun sirsak (Annona muricata L.) terhadap bakteri penyebab bisul (Staphylococcus aureus) dengan metode simplex lattice design. Skripsi. Universitas Muhammadiyah Yogyakarta, Yogyakarta.

Kil, YS, Pham, ST., Seo, EK. & Jafari, M. (2017). Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities. Archives of Pharmacal Research.

Kuncahyo, I. (2011). Optimasi campuran carbopol941 dan HPMC dalam formulasi sediaan gel ekstrak daun jambu mete secara simplex lattice design. Jurnal Farmasi Indonesia, 8(1): 1-12.

Kusuma, SAF, Iskandar, Y., & Dewanti, MA. (2018). The ethanolic extract of ashitaba stem (angelica keiskei) as future antituberculosis. Journal of Advanced Pharmaceutical Technology and Research, 9(1): 37-41.

Lestari, ABS., Susanti, LU & Dwiatmaka, Y., (2012). Optimasi pelarut etanol-air dalam proses ekstraksi herba pegagan (Centella asiatica (L.) Urban.) pada suhu terukur. Bionatura-Jurnal Ilmu-ilmu Hayati dan Fisik, 14(2): 87-93.

Lestari, FA, Hajrin, W., & Hanifa, NI. (2020). Optimasi formula krim ekstrak daun katuk (Sauropus androgynus) variasi konsentrasi asam stearat, trietanolamin, dan gliserin. Jurnal Kefarmasian Indonesia, 10(2): 110-119. DOI: https://doi.org/10.22435/jki.v10i2.2496.

Li, L., Aldini, G., Carini, M., Chen, CYO, Chun, HK, Cho, SM., & Yeum, KJ., (2009). Characterisation, extraction efficiency, stability and antioxidant activity of phytonutrients in Angelica keiskei. Food chemistry, 115(1), 227-232.

Martyasari, NWR, Andayani, Y., & Hajrin, W., (2019). Optimization of hand sanitizer gel formula of tekelan leaves extract (Chromoleana odorata) using simplex lattice design method. Bali Medical Journal, 8(3): 769-773. DOI:10.15562/bmj.v8i3.1598.

Osborne, DW. & Amann, AH., (1990). Topical Drug Delivery Formulation: Semisolid Products, Volume 92, 382-388. Marcel Dekker Inc., New York.

Paye, M., Barel, AO & Maibach, HI (2001). Handbook of Cosmetics Sciences and Technology, 2nd Edition, Marcel Dekker Inc, New York.

Ramadhani, RA., Riyadi, DHS, Triwibowo, B., & Kusumaningtyas, RD. (2017). Review pemanfaatan design expert untuk optimasi komposisi campuran minyak nabati sebagai bahan baku sintesis biodesel. Jurnal Teknik Kimia Lingkungan, 1(1): 11-16.

Rosyadi, A. (2013). Optimasi kombinasi minyak atsiri bunga kenanga dengan herba kemangi dalam gel sebagai repelan nyamuk Aedes aegypti dengan metode simplex lattice design. Skripsi. Universitas Muhammadiyah Purwokerto, Purwokerto.

Rowe, CR., Sheskey, PJ & Quinn, ME. (2009). Handbook of Pharmaceutical Excipients, 6th Edition. Pharmaceutical Press, London.

Setiawan, PYB (2013). Penerapan metode simplex lattice design dalam penentuan komposisi pelarut etanol-air pada proses ekstraksi daun papaya (Carica papaya) dengan respon aktivitas larvasida nyamuk Aedes aigypti. Skripsi. Universitas Gadjah Mada, Yogyakarta.

Suhartati, R. & Virgianti, DP (2015). Daya hambat ekstrak etanol 70% daun ashitaba (Angelica keiskei) terhadap bakteri Staphylococcus aureus yang diisolasi dari luka diabetes. Jurnal Kesehatan Bakti Tunas Husada, 14(1): 162-171. DOI: http://dx.doi.org/10.36465/jkbth.v14i1.134.

Sulaiman, TNS & Kuswahyuning, R. (2008). Teknologi dan Formulasi Sediaan Semipadat. Pustaka Laboratorium Teknologi Farmasi Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta, Indonesia.

Suryani, Nafisah A. & ManaÃ¢â¬â¢an S. (2017). Optimasi Formula Gel Antioksidan Ekstrak Etanol Buah Bligo (Benincasa hispida) dengan Metode Simplex Lattice Design (SLD). Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 3(2): 150-156. doi:10.22487/j24428744.2017.v3.i2.8815

Wirasisya, DG, Juliantoni, Y. & Hajrin, W., (2018). Pengaruh dua metode pengeringan pada aktivitas antibakteri ashitaba (angelica keiskei) terhadap Streptococcus mutans. Jurnal Farmasi Galenika, 4(1): 18-25.

Zhang, L., Jiang, Y., Pang, X., Hua, P., Gao, X., Li, Q. & Li, Z., (2019). Simultaneous optimization of ultrasound-assisted extraction for flavonoids and antioxidant activity of angelica keiskei using response surface methodology (RSM). Molecules, 24(19): 3461.

License

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

Most read articles by the same author(s)

Trasna Arman Jani, Aliefman Hakim, Yohanes Juliantoni, Formulation and Evaluation of Antioxidant Peel-Off Face Mask Containing Red Dragon Fruit Rind Extract (Hylocereus polyrhizus Haw.) , Jurnal Biologi Tropis: Vol. 20 No. 3 (2020): September - Desember
Nisa Isneni Hanifa, Dyke Gita Wirasisya, Arinda Eka Muliani, Septia Budi Utami, Anggit Listyacahyani Sunarwidhi, Phytochemical Screening of Decoction and Ethanolic Extract of Amomum dealbatum Roxb. Leaves , Jurnal Biologi Tropis: Vol. 21 No. 2 (2021): Mei - Agustus
Yohanes Juliantoni, Wahida Hajrin, Windah Anugrah Subaidah, Nanoparticle Formula Optimization of Juwet Seeds Extract (Syzygium cumini) using Simplex Lattice Design Method , Jurnal Biologi Tropis: Vol. 20 No. 3 (2020): September - Desember
Dyke Gita Wirasisya, Nisa Isneni Hanifa, Wahida Hajrin, Ethnobotanical Study of Medicinal Plants Used to Treat Degenerative Disease in East Lombok , Jurnal Biologi Tropis: Vol. 20 No. 3 (2020): September - Desember
Mariama Fitriana, Wahida Hajrin, Windah Anugrah Subaidah, Sucilawaty Ridwan, Eskarani Tri Pratiwi, Uji Antiinflamasi Ekstrak Etanol Ashitaba (Angelica keiskei) Secara In Vitro , Jurnal Biologi Tropis: Vol. 24 No. 2b (2024): Special Issue
Dyke Gita Wirasisya, Amni Hamid, Muhamad Haikhal, Agriana Rosmalina Hidayati, Anggit Listyacahyani Sunarwidhi, Nisa Isneni Hanifa, Anti-Stapylococcus Epidermidis of Methanolic Extracts from Some East Lombok Medicinal Plants , Jurnal Biologi Tropis: Vol. 23 No. 2 (2023): April-June
Handa Muliasari, Nisa Isneni Hanifa, Wahida Hajrin, Mahacita Andanalusia, Agriana Rosmalina Hidayati, Determination of Antioxidants by DPPH Scavenging Activity of Ashitaba Herb (Angelica keiskei) Methanol Extract , Jurnal Biologi Tropis: Vol. 23 No. 4 (2023): October - December
Weny Syafitri Utari, Eskarani Tri Pratiwi, Windah Anugrah Subaidah, Sucilawaty Ridwan, Optimization of Cream Formula Extract Sargassum Crassifolium Using Varied Concentrations of Glyceryl Monostearate and Triethanolamine Emulgators With The Simplex Lattice Design Method , Jurnal Biologi Tropis: Vol. 25 No. 3 (2025): Juli-September
Acyuta Pramesthi Asmara Sayidina Syahputri, Wahida Hajrin, Windah Anugrah Subaidah, Optimization of Lip Balm Formula From Buni Fruit Extract (Antidesma bunius L. Spreng) with A Combination of Beeswax Lanolin , Jurnal Biologi Tropis: Vol. 25 No. 3 (2025): Juli-September
Ni Made Ayu Dinda Permatasari, Handa Muliasari, Nisa Isneni Hanifa, Agriana Rosmalina Hidayati, Dedianto Hidajat, Wahida Hajrin, Adila Rizkika, Anti-Radical Activity Test of Fractions from Ashitaba Herbs (Angelica keiskei) , Jurnal Biologi Tropis: Vol. 24 No. 4 (2024): Oktober - Desember

1 2 > >>

Application of Simplex Lattice Design Method on The Optimisation of Deodorant Roll-on Formula of Ashitaba (Angelica keiskei)

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow