The Marine Organisms as Potential Sources of Inhibits ACE on Hypertension Patient

Alma Dyah Perwita; Adam Trojan  Alisyahbana; Adinda Ilsa  Maulida; Alfia  Mawaddah; Ali Ramzi; Legis Ocktaviana Saputri

doi:10.29303/jbt.v23i1.6162

The Marine Organisms as Potential Sources of Inhibits ACE on Hypertension Patient

Authors

Alma Dyah Perwita , Adam Trojan Alisyahbana , Adinda Ilsa Maulida , Alfia Mawaddah , Ali Ramzi , Legis Ocktaviana Saputri

DOI:

10.29303/jbt.v23i1.6162

Published:

2023-12-20

Issue:

Vol. 23 No. 1 (2023): Special Issue

Keywords:

Hypertension marine organism, inhibit ACE, potential sources, treatment.

Articles

Downloads

How to Cite

Perwita, A. D., Alisyahbana, A. T. ., Maulida, A. I., Mawaddah, A. ., Ramzi, A., & Saputri, L. O. (2023). The Marine Organisms as Potential Sources of Inhibits ACE on Hypertension Patient. Jurnal Biologi Tropis, 23(1), 490–498. https://doi.org/10.29303/jbt.v23i1.6162

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Abstract:

Hypertension is a condition of chronic high blood pressure in the systemic arteries which is a major risk factor for cardiovascular disease, kidney disorders, and death. There are two types of hypertension, the primary hypertension is thought to be caused by hereditary factors, age, gender, race, and an unhealthy lifestyle. Secondary hypertension is caused by an obvious cause. The prevalence of hypertension in Indonesia is quite high with the highest incidence rate in South Kalimantan (44,1%) and the lowest in Papua (22,2%). The pathophysiology of hypertension involves the enzyme Angiotensin Converting Enzyme (ACE) which plays a role in regulating blood pressure. The process of converting Angiotensinogen to Angiotensin I, then Angiotensin II by ACE can cause vasoconstriction and fluid retention, which contribute to hypertension. The changes in circulation and blood vessel structure have played a role in the risk of hypertension complications, including stroke. The marine organisms such as fish, shellfish, cephalopods, seaweed, and algae contain peptides with antihypertensive, anticoagulant, antithrombotic, and hypercholesterolemic activities. For example, hydrolyzate of the jellyfish, Rhopilema esculentum can inhibit ACE with a high level of effectiveness. The current hypertension treatment often uses synthetic drugs such as ACE inhibitors and Angiotensin Receptor Blockers (ARBs), but these have undesirable side effects. Therefore, bioactive peptides from marine organisms can be an efficient and safe natural alternative. The research on protein hydrolysates from various sources has found ACE inhibitory activity and several peptides such as Trp-Pro-Met-Gly-Phe (WPMGF) and APP, KPLL, and VYPFPGPIPNSLPQNIPP were identified to have strong ACE inhibitory activity. These findings indicate the potential use of bioactive peptides from marine organisms as a natural alternative for the treatment and prevention of hypertension.

References

Bahrami, Y., Zhang, W., & MM Franco, C. (2018). Distribution of saponins in the sea cucumber Holothuria lessoni; the body wall versus the viscera, and their biological activities. Marine drugs, 16(11), 423. DOI: 10.3390/md16110423.

Dewi, N. P. U. S., Amandari, I. G. A. A. E., Krisnayanti, M. W., & Sarasmita, M. A. (2018). Aliskiren: Direct renin inhibitor baru pada terapi hipertensi. Hang Tuah Medical Journal, 16(1), 18-27. DOI: 10.30649/htmj.v16i1.76.

Fagbohun, O. F., Joseph, J. S., Oriyomi, O. V., & Rupasinghe, H. V. (2023). Saponins of North Atlantic Sea Cucumber: Chemistry, Health Benefits, and Future Prospectives. Marine Drugs, 21(5), 262. DOI: 10.3390/md21050262.

Festa, M., Sansone, C., Brunet, C., Crocetta, F., Di Paola, L., Lombardo, M., ... & Albini, A. (2020). Cardiovascular active peptides of marine origin with ACE inhibitory activities: Potential role as anti-hypertensive drugs and in prevention of SARS-CoV-2 infection. International journal of molecular sciences, 21(21), 8364. DOI: 10.3390/ijms21218364.

Gabb, G. (2020). What is hypertension?. Australian Prescriber, 43(4), 108. DOI: 10.18773/austprescr.2020.025.

Ghanbari, R., Zarei, M., Ebrahimpour, A., Abdul-Hamid, A., Ismail, A., & Saari, N. (2015). Angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidant activities of sea cucumber (Actinopyga lecanora) hydrolysates. International journal of molecular sciences, 16(12), 28870-28885. DOI: 10.3390/ijms161226140.

Han, X. Q., Zhang, L. Y., Ding, L., Shi, H. H., Xue, C. H., Zhang, T. T., & Wang, Y. M. (2019). Synergistic effect of sea cucumber saponins and EPA-enriched phospholipids on insulin resistance in high-fat diet-induced obese mice. Food & Function, 10(7), 3955-3964. DOI: 10.1039/c9fo01147a.

Harrison, D. G., Coffman, T. M., & Wilcox, C. S. (2021). Pathophysiology of hypertension: the mosaic theory and beyond. Circulation research, 128(7), 847-863. DOI: https://doi.org/10.1161/CIRCRESAHA.121.318082

Husada, S., Riview, L., & Puspitasari, P. N. (2020). Hubungan Hipertensi Terhadap Kejadian Stroke. Jurnal Ilmiah Kesehatan Sandi Husada, 12, 922–926. https://doi.org/10.35816/jiskh.v10i2.435

Kartika, M., Subakir, S., & Mirsiyanto, E. (2021). Faktor-Faktor Risiko Yang Berhubungan Dengan Hipertensi Di Wilayah Kerja Puskesmas Rawang Kota Sungai Penuh Tahun 2020. Jurnal Kesmas Jambi, 5(1), 1-9. DOI: 10.22437/jkmj.v5i1.12396.

Kemenkes. (2021). Pedomanan Nasional Pelayanan Kedokteran Tata Laksana Hipertensi Dewasa', Kementerian Kesehatan RI, pp. 1–85.

Khalil, H. and Zeltser, R. (2023) Antihypertensive Medications, StatPearls. Available at: https://www.ncbi.nlm.nih.gov/books/NBK554579/.

Li, J., Li, Q., Li, J., & Zhou, B. (2014). Peptides derived from Rhopilema esculentum hydrolysate exhibit angiotensin converting enzyme (ACE) inhibitory and antioxidant abilities. Molecules, 19(9), 13587-13602. DOI: 10.3390/molecules190913587

Li, J., Liu, Z., Zhao, Y., Zhu, X., Yu, R., Dong, S., & Wu, H. (2018). Novel natural angiotensin converting enzyme (ACE)-inhibitory peptides derived from sea cucumber-modified hydrolysates by adding exogenous proline and a study of their structure–activity relationship. Marine Drugs, 16(8), 271. DOI: 10.3390/md16080271.

Lin, P., Shen, N., Yin, F., & Guo, S. D. (2022). Sea cucumber-derived compounds for treatment of dyslipidemia: A review. Frontiers in Pharmacology, 13, 1000315. DOI: 10.3389/fphar.2022.1000315.

Liu, X., Zhang, M., Jia, A., Zhang, Y., Zhu, H., Zhang, C., ... & Liu, C. (2013). Purification and characterization of angiotensin I converting enzyme inhibitory peptides from jellyfish Rhopilema esculentum. Food Research International, 50(1), 339-343. DOI: 10.1016/j.foodres.2012.11.002.

Meng, J., Hu, X., Zhang, T., Dong, P., Li, Z., Xue, C., ... & Wang, Y. (2018). Saponin from sea cucumber exhibited more significant effects than ginsenoside on ameliorating high fat diet-induced obesity in C57BL/6 mice. MedChemComm, 9(4), 725-734. DOI: 10.1039/c7md00653e.

Oparil, S., Acelajado, M. C., Bakris, G. L., Berlowitz, D. R., Cífková, R., Dominiczak, A. F., ... & Whelton, P. K. (2019). HHS public access. Hypertension. Nat Rev Dis Prim [Internet], 22(4), 1-48. DOI: 10.1038/nrdp.2018.14.Hypertension.

Pujiastuti, D. Y., Ghoyatul Amin, M. N., Alamsjah, M. A., & Hsu, J. L. (2019). Marine organisms as potential sources of bioactive peptides that inhibit the activity of angiotensin I-converting enzyme: a review. Molecules, 24(14), 2541. DOI: 10.3390/molecules24142541.

Sadegh Vishkaei, M., Ebrahimpour, A., Abdul-Hamid, A., Ismail, A., & Saari, N. (2016). Angiotensin-I converting enzyme (ACE) inhibitory and anti-hypertensive effect of protein hydrolysate from Actinopyga lecanora (Sea Cucumber) in rats. Marine drugs, 14(10), 176. DOI: 10.3390/md14100176.

Soesanto, E. and Zulino, S. (2021) 'Cucumber and honey soaking reduces hypertension in the elderly', South East Asia Nursing Research, 3(2), p. 45. DOI: 10.26714/seanr.3.2.2021.45-50.

Wijesekara, I., & Kim, S. K. (2010). Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: Prospects in the pharmaceutical industry. Marine drugs, 8(4), 1080-1093. DOI: https://doi.org/10.3390/md8041080.

Yonata, A., & Pratama, A. S. P. (2016). Hipertensi sebagai faktor pencetus terjadinya stroke. Jurnal Majority, 5(3), 17-21.

Yu, F., Zhang, Z., Luo, L., Zhu, J., Huang, F., Yang, Z., ... & Ding, G. (2018). Identification and molecular docking study of a novel angiotensin-I converting enzyme inhibitory peptide derived from enzymatic hydrolysates of Cyclina sinensis. Marine Drugs, 16(11), 411. DOI: 10.3390/md16110411

Zhuang, Y., Sun, L., & Li, B. (2012). Production of the angiotensin-I-converting enzyme (ACE)-inhibitory peptide from hydrolysates of jellyfish (Rhopilema esculentum) collagen. Food and Bioprocess Technology, 5, 1622-1629. DOI: 10.1007/s11947-010-0439-9.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

Most read articles by the same author(s)

Ali Ramzi, Chikungunya: Diagnostic, Treatment and Challenge in Indonesia , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Jihan Alifa Rahma, Adinda Ilsa Maulida, Alma Dyah Perwita, Baiq Ayu Rahmawati, Clara Nadila, Herodya Lajunee Fesmia, Ni Made Utami Wulandari, Zhayyin Palna Rial Novsyaini, Indana Eva Ajmala, Precocious Puberty: Etiology and Current Treatment , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Baiq Henny Salim Alawiyah, Alfia Mawaddah, Annisa Diyanabila Indrasari, Ayundha Rizky Lestari, Diki Wahyudi, Fatikha Rudia Ahda, I Gede Aditya Satrya Bhuwana Cakra, Ni Made Ayu Shinta Dewi, Rida Dwi Arista, Puji Widyastuti, Talitha Syahla, Vanessa Essianda, Yunita Hapsari, Most Common Sexually Transmitted Infections in LGBT , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Baiq Ayu Rahmawati, Amelia Wahyu Maharani, Ali Ramzi, Muhammad Rizkinov Jumsa , Factors That Determine the Successful Management of Ectopic Pregnancy Through Methotrexate Injections , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Adinda Ilsa Maulida, Ali Ramzi, Amrullah Muliawan H, Baiq Ghassani Kayla, Clara Nadila, Dinda Salsabila, Febbi Anggy, Herodya Lajunee Fesmia, Jihan Alifa Rahma, Trisna Ayu Kurnia Putri, Wina Aryslia Fakar, Zulfa Hasyimiyyah Ihtisyam, Nurhidayati Nurhidayati, Giant Cell Tumor: Pathogenesis and Clinical Manifestation , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Ali Ramzi, Ilsa Hunaifi, Diagnosis and Management of Post Traumatic Epilepsy , Jurnal Biologi Tropis: Vol. 24 No. 4 (2024): Oktober - Desember
Made Raditya Arhya Putra, Legis Ocktaviana Saputri, Teguh Budi Wicaksono, Kadek Nandita Nugraha, Ajeng Ayu Putri, Rika Kamila Salsabila, Puspa Zalika Fidelia, Marine Organisms with Anti-Amyloid Effect Through Their Role as BACE1 Inhibitors for Preventive Effort in Alzheimer’s Disease: A Literature Review , Jurnal Biologi Tropis: Vol. 24 No. 4 (2024): Oktober - Desember
Mutia Novisma, Legis Ocktaviana Saputri, Nisa Isneni Hanifa, In Vivo Analgetic Activity Test of Malacca Stem Bark Extract (Phyllanthus emblica L.) by Acetic Acid Induction Method , Jurnal Biologi Tropis: Vol. 24 No. 4 (2024): Oktober - Desember

The Marine Organisms as Potential Sources of Inhibits ACE on Hypertension Patient

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow