Profile of the Anti-inflammatory Mediator Interleukin-10 (IL-10) in Patients Suspected of Covid-19

Pauzan Pauzan; Edy Kurniawan

doi:10.29303/jbt.v24i4.7658

Profile of the Anti-inflammatory Mediator Interleukin-10 (IL-10) in Patients Suspected of Covid-19

Authors

Pauzan Pauzan , Edy Kurniawan

DOI:

10.29303/jbt.v24i4.7658

Published:

2024-10-15

Issue:

Vol. 24 No. 4 (2024): Oktober - Desember

Keywords:

Anti-inflammatory mediator, cytokin IL-10, suspected Covid-19.

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Pauzan, P., & Kurniawan, E. (2024). Profile of the Anti-inflammatory Mediator Interleukin-10 (IL-10) in Patients Suspected of Covid-19. Jurnal Biologi Tropis, 24(4), 365–370. https://doi.org/10.29303/jbt.v24i4.7658

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Abstract

Severe acute respiratory syndrome corona virus 2 (SARSCOV-2) is a virus that causes corona virus desease (Covid-19), namely a respiratory sindrome desease that comes from the beta corona virus group. A serious problem with Sarscov-2 infection is when a cytokine storm appears which is produced as the body’s response to an inflammatory reaction, but the presence of interleukin (cytokine)-10 as an anti-inflammatory cytokine can suppress inflammatory reactions to avoid cytokine storms. The study's objective was to characterize IL-10 levels in people who may have Covid-19. The research method is to use an analytical survey with a retrospective design. Interleukin-10 levels were measured utilizing the ELISA (Enzime Linked Immunosorbant Assay) method. Result: The average level of IL-10 in SARSCOV-2 utilizing the Real Time Polymerase Chain Reaction (RT-PCR) method to detect positive Covid-19 suspect samples (83.16 pg/ml) was higher than SARSCOV-2 negative Covid-19 suspects (81.03 pg/ml). Conclusion: the comparison of IL-10 levels in positive Covid-19 suspects and negative Covid-19 suspects using the RT-PCR technique has an insignificant difference in levels because naturally Pro- and anti-inflammatory cytokines' reciprocal responses show that the immune response of the samples from suspected Covid-19 patients used is still very strong (IL-10).

References

Bosch, B. J., van der Zee, R., de Haan, C. A., & Rottier, P. J. (2003). The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex. Journal of Virology, 77(16), 8801–8811 https://doi.org/10.1128/jvi.77.16.8801-8811.2003.

Channappanavar, R., & Perlman, S. (2017). Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Seminars in Immunopathology, 39(5), 529–539 https://doi.org/10.1007/s00281-017-0629-x.

Chen, L. D., Wei, X. J., Cai, Y. Q., Yao, W. Z., Wang, M. H., Huang, Q. F., & Zhang, X. B. (2020). Association between cytokine profiles and lung injury in COVID-19 pneumonia . Respiratory Research, 21(1), 1–8. https://doi.org/10.1186/s12931-020-01465-2.

Covid-19 Hotline. (2020). Retrieved from https://covid19.go.id/

Cucinotta, D., & Vanelli, M. (2020). WHO declares COVID-19 a pandemic. Acta Biomedica, 91(1), 157–160 https://doi.org/10.23750/abm.v91i1.9397.

Dhar, S., V, K., Damodar, S., Gujar, S., & Das, M. (2021). IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression. Heliyon, 7(2), 1-5. doi:https://10.1016/j.heliyon.2021.e06155

Dodoo, D., Omer, F. M., Todd, J., Akanmori, B. D., Koram, K. A., & Riley, E. M. (2002). Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falciparum malaria. Journal of Infectious Diseases, 185(7), 971–979 . doi:https://doi.org/10.1086/339408

Fadhilah, N., Soegiarto, G., Budhy, T., & Kes, M. (2021). Potential of IL-10 as Targeted Therapy in Severe COVID-19 Patients. Malaysian Journal of Medicine and Health Sciences, 17, 165-168. Retrieved from https://scholar.unair.ac.id/en/publications/potential-of-il-10-as-targeted-therapy-in-severe-covid-19-patient

Gemmati, D., Bramanti, B., Serino, M. L., Secchiero, P., Zauli, G., & Tisato, V. (2020). COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males? Int. J. Mol. Sci, 21(10), 1–23. doi:https://10.3390/ijms21103474

He, S., Zhou, C., Lu, D., Yang, H., Xu, H., Wu, G., . . . Wu, X. (2020). Relationship between chest CT manifestations and immune response in COVID-19 patients. International Journal of Infectious Diseases, 98, 125–129. doi:https://doi.org/10.1016/j.ijid.2020.06.059

Mau, F., & Tallan, M. M. (2016). Gambaran Peningkatan Kadar Inter Leukin-10 (IL-10) dan Tumor Necrosis Faktor – Alfa (TNF-α) dengan Gejala Klinis pada Penderita Malaria. Buletin Penelitian Kesehatan , 44(3), 181–186 . doi:https://doi.org/10.22435/bpk.v44i3.4806.

Mouna, B. A., Awatef Ben, J., Walid, S., Chihebeddine, R., Ridha, O., Hedi, G., . . . Mustapha, F. (2022). Deciphering the balance of IL-6/IL-10 cytokines in severe to critical COVID-19 patients. Immunobiology, 227(4), 1-12. doi:https://doi.org/10.1016/j.imbio.2022.152236

Rosyanti, L., & Hadi, I. (2020). The Immunity Response and Severe Acute Respiratory Syndrome Coronavirus-2 Cytokine Storm Literature Review. Jurnal Kesehatan Madani Medika, 11(2), 176–201. Retrieved from www.jurnalmadanimedika.ac.id

Sama, I. E., Ravera, A., Santema, B. T., Goor, H. v., Maaten, J. M., Cleland, J. G., . . . Filippatos, G. (2020). Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors. Eur Heart J, 41(19), 1810-1817. doi:https://10.1093/eurheartj/ehaa373

Wu, F., Zhao, S., Yu, B., Chen, Y. M., Wang, W., Song, Z. G., . . . & Zhang, Y. Z. (2020). A new coronavirus associated with human respiratory disease in China. Nature, 579(7798) , 265–269 https://doi.org/10.1038/s41586-020-2008-3.

Zeng, Z., Yu, H., Chen, H., Qi, W., Chen, L., Chen, G., . . . Wu, D. (2020). Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China. Critical Care, 24(1) , 1–12 https://doi.org/10.1186/s13054-020-03255-0.

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Profile of the Anti-inflammatory Mediator Interleukin-10 (IL-10) in Patients Suspected of Covid-19

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