Functional Disorders of the Biliary System: Biliary Dyskinesia and Sphincter of Oddi Dysfunction

Romy Healthy Mikailla; Baiq Nurhandini Wulandari; Shira Putri Wardana; Nadine Aisyah Sultan Firdaus; Panji Sena Ramadhan; Hasna Tazkia  Aghni; Nurhidayati Nurhidayati

doi:10.29303/jbt.v25i4.9955

Functional Disorders of the Biliary System: Biliary Dyskinesia and Sphincter of Oddi Dysfunction

Authors

Romy Healthy Mikailla , Baiq Nurhandini Wulandari , Shira Putri Wardana , Nadine Aisyah Sultan Firdaus , Panji Sena Ramadhan , Hasna Tazkia Aghni , Nurhidayati Nurhidayati

DOI:

10.29303/jbt.v25i4.9955

Published:

2025-10-01

Issue:

Vol. 25 No. 4 (2025): Oktober-Desember

Keywords:

Biliary system, Biliary dyskinesia, Sphincter of Oddi dysfunction

Articles

Downloads

How to Cite

Mikailla, R. H., Wulandari, B. N., Wardana, S. P., Firdaus, N. A. S., Ramadhan, P. S., Aghni, H. T., & Nurhidayati, N. (2025). Functional Disorders of the Biliary System: Biliary Dyskinesia and Sphincter of Oddi Dysfunction. Jurnal Biologi Tropis, 25(4), 4791–4799. https://doi.org/10.29303/jbt.v25i4.9955

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Functional biliary disorders are conditions caused by biliary dysmotility without the presence of gallstones, sludge, microlithiasis, or microcrystalline disease. The most common functional biliary disorders are biliary dyskinesia and sphincter of Oddi dysfunction. This study employed a literature review method by searching and reviewing various references from online databases such as PubMed, Google Scholar, and ProQuest. Functional biliary disorders such as biliary dyskinesia and sphincter of Oddi dysfunction often cause biliary pain without gallstones. Although not life-threatening, these disorders can affect quality of life and require appropriate management. Pharmacological treatments such as NSAIDs and ursodeoxycholic acid (UDCA) can help alleviate symptoms of biliary disorders, but surgical interventions such as cholecystectomy and sphincterotomy may be necessary for more severe cases. The choice of treatment method should take into account the risks and complications, and be carried out by an experienced medical team.

References

Abaturov, A. E., Kryuchko, T. O., Nikulina, G. V., Makhotina, O. L., & Konoplia, A. I. (2020). Regulation of microRNA expression level by choleretic therapy in functional disorders of the gallbladder and Oddi’s sphincter in children. Wiadomości Lekarskie, 73(1), 41–45. https://doi.org/10.36740/wlek202001107

Abdelhamid, M. O., Thiels, C. A., & Bingener, J. (2018). Is functional gallbladder disease truly increasing? Results from the Rochester Epidemiology Project. The American Journal of Surgery, 216(5), 932–934. https://doi.org/10.1016/j.amjsurg.2018.04.001

Behar, J. (2013). Physiology and pathophysiology of the biliary tract: The gallbladder and sphincter of Oddi—A review. ISRN Physiology, 2013, 1–15. https://doi.org/10.1155/2013/837630

Behar, J., Corazziari, E., Guelrud, M., Hogan, W., Sherman, S., & Toouli, J. (2006). Functional gallbladder and sphincter of Oddi disorders. Gastroenterology, 130(5), 1498–1509. https://doi.org/10.1053/j.gastro.2006.03.034

Bistritz, L., & Bain, V. G. (2006). Sphincter of Oddi dysfunction: Managing the patient with chronic biliary pain. World Journal of Gastroenterology, 12(24), 3793–3802. https://doi.org/10.3748/wjg.v12.i24.3793

Björkström, N. K. (2022). Immunobiology of the biliary tract system. Journal of Hepatology, 77(6), 1657–1669. https://doi.org/10.1016/j.jhep.2022.08.018

Clark, C. J. (2019). An update on biliary dyskinesia. Surgical Clinics of North America, 99(2), 203–214. https://doi.org/10.1016/j.suc.2018.11.004

Crittenden, J. P., & Dattilo, J. B. (2023). Sphincter of Oddi dysfunction. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK557871/

Coucke, E. M., Akbar, H., Kahloon, A., & Kahloon, R. A. (2022). Biliary obstruction. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK539698/

Fraquelli, M., Pagliarulo, M., Colucci, A., Paggi, S., & Conte, D. (2016). Non-steroid anti-inflammatory drugs for biliary colic. Cochrane Database of Systematic Reviews, 2016(9), CD006390. https://doi.org/10.1002/14651858.CD006390.pub2

Hansel, S. L., & DiBaise, J. K. (2010). Functional gallbladder disorder: Gallbladder dyskinesia. Gastroenterology Clinics of North America, 39(2), 369–379. https://doi.org/10.1016/j.gtc.2010.02.002

Housset, C., Chrétien, Y., Debray, D., & Chignard, N. (2016). Functions of the gallbladder. Comprehensive Physiology, 6(3), 1549–1577. https://doi.org/10.1002/cphy.c150050

Kegnæs, M., Novovic, S., & Shabanzadeh, D. M. (2023). Dysfunction of biliary sphincter of Oddi—Clinical, diagnostic and treatment challenges. Journal of Clinical Medicine, 12(14), 4802. https://doi.org/10.3390/jcm12144802

Kim, Y. M., Choi, S. K., Kim, H. S., Lee, J. H., Kim, D. H., & Kim, H. J. (2020). Litholytic agents as an alternative treatment modality in patients with biliary dyspepsia. Medicine, 99(34), e21698. https://doi.org/10.1097/md.0000000000021698

Kosmidis, C. S., Koimtzis, G. D., Kosmidou, M. S., Ieridou, F., Koletsa, T., Zarampouka, K. T., Georgakoudi, E., & Kesisoglou, I. (2017). Gallbladder hypoplasia, a congenital abnormality of the gallbladder: A case report. American Journal of Case Reports, 18, 905–963. https://doi.org/10.12659/ajcr.905963

Kim, J. V., & Wu, G. Y. (2022). Update on sphincter of Oddi dysfunction: A review. Journal of Clinical and Translational Hepatology, 10(3), 515–521. https://doi.org/10.14218/JCTH.2021.00167

Lam, R., Keeratibharat, N., & Chansangrat, J. (2021). Gallbladder disorders: A comprehensive review. Disease-a-Month, 67(7), 101130. https://doi.org/10.1016/j.disamonth.2021.101130

Melzer, M., Toner, R., Lacey, S., Bettany, E., Rait, G., & Shaw, S. (2007). Biliary tract infection and bacteraemia: Presentation, structural abnormalities, causative organisms and clinical outcomes. Postgraduate Medical Journal, 83(986), 773–776. https://doi.org/10.1136/pgmj.2007.064683

Morgan, K. A., & Adams, D. B. (2019). Biliary dyskinesia and sphincter of Oddi dysfunction. In C. J. Yeo, D. B. Adams, J. L. Matthews, & J. S. Broaddus (Eds.), Shackelford’s surgery of the alimentary tract (8th ed., Vol. 2, pp. 1110–1120). Elsevier. https://doi.org/10.1016/B978-0-323-40232-3.00110-2

Ott, L., Krüger, S., & Lindner, C. (2022). Triple gallbladder with heterotopic gastric mucosa: A case report. BMC Pediatrics, 22(1), 238. https://doi.org/10.1186/s12887-022-03122-7

Picchi, E., Di Lazzaro, D., & Larghi, A. (2023). Triple gallbladder: Radiological review. Clinical Journal of Gastroenterology, 16(5), 629–640. https://doi.org/10.1007/s12328-023-01829-3

Richmond, B. K., & Walker, A. (2021). Biliary dyskinesia: Current perspectives and future directions. American Surgeon, 87(6), 954–960. https://doi.org/10.1177/0003134820971617

Telega, G. (2006). Biliary dyskinesia in pediatrics. Current Gastroenterology Reports, 8(2), 172–176. https://doi.org/10.1007/s11894-006-0015-7

Thiels, C. A., Habermann, E. B., & Bingener, J. (2016). Functional gallbladder disease: Operative trends and short-term outcomes. Surgery, 160(1), 100–105. https://doi.org/10.1016/j.surg.2016.03.005

Vij, M., & Rela, M. (2020). Biliary atresia: Pathology, etiology and pathogenesis. Future Science OA, 6(5), FSO466. https://doi.org/10.2144/fsoa-2019-0153

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

Most read articles by the same author(s)

Hanum Retno Hanifah, Yunita Hapsari, Shira Putri Wardana, Muhammad Haikal, Human Papillomavirus (HPV) Infection and The Spectrum of Diseases It Causes: A Literature Review , Jurnal Biologi Tropis: Vol. 25 No. 4 (2025): Oktober-Desember
Ida Ayu Andara Damayanti, I Nyoman Dio Yudha Prawira, Syabila Andini, Hanum Retno Hanifah, I Made Danuarta Wiguna, Baiq Nurhandini Wulandari, Khansa Aulia Sabrina, Andi Husnul Khotimah, Shira Putri Wardana, Rifqi Rizqullah, Muhammad Haikal, Cerebral Palsy: Risk Factors, Pathophysiology, Clinical Manifestations, Diagnosis, and Management , Jurnal Biologi Tropis: Vol. 25 No. 4a (2025): Special Issue
Adinda Ilsa Maulida, Ali Ramzi, Amrullah Muliawan H, Baiq Ghassani Kayla, Clara Nadila, Dinda Salsabila, Febbi Anggy, Herodya Lajunee Fesmia, Jihan Alifa Rahma, Trisna Ayu Kurnia Putri, Wina Aryslia Fakar, Zulfa Hasyimiyyah Ihtisyam, Nurhidayati Nurhidayati, Giant Cell Tumor: Pathogenesis and Clinical Manifestation , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Panji Sena Ramadhan, Aziza Chantiqka Aulia Nursiain, Shira Putri Wardana, Tsania Zulfa Salsabila, Anak Agung Ayu Regina Larasati, Clinical Status Asthmaticus as a Respiratory Emergency: Management in Pediatric and Adult Populations , Jurnal Biologi Tropis: Vol. 25 No. 4a (2025): Special Issue
Baiq Nurhandini Wulandari, Romy Healthy Mikailla, Shira Putri Wardana, Nadine Aisyah S.F., Panji Sena R., Hasna Tazkia Aghni, Nurhidayati Nurhidayati, Chronic Anal Fissure: A Literature Review , Jurnal Biologi Tropis: Vol. 25 No. 4 (2025): Oktober-Desember
Baiq Suyatmin Rahma, Nurhidayati Nurhidayati, Mahacita Andanalusia, The Relatioship Between Medication Adherence of Stroke Patients and Recurrent Stroke Incidance At Siti Hajar Islamic Hospitas Mataram , Jurnal Biologi Tropis: Vol. 25 No. 3 (2025): Juli-September
Shira Putri Wardana, Lalu Dane Pemban Pardoe, M. Rizky Yolanda, Arwinda Febri Yulianti, Philip Habib, Tonsillitis in Focus: Clinical Features, Diagnostic Methods, and Evidence-Based Therapy , Jurnal Biologi Tropis: Vol. 25 No. 4 (2025): Oktober-Desember
Lale Nubya Nitzana, Mielosita Hasanah, Romy Healthy Mikailla, Yunan Prabu Jaya Anugrah, Janiya Abdila Ilmiah, Indana Eva Ajmala, Lung Abscess: Literature Review of Risk Factors, Classification, Clinical Manifestations, Diagnosis, and Prevention , Jurnal Biologi Tropis: Vol. 25 No. 4 (2025): Oktober-Desember
Baiq Nurhandini Wulandari, Novrita Padauleng, Rizka Vidya Lestari, Baiq Ratna Kumaladewi, The Association Between BRCA1 Expression and ER/PR Status in Breast Cancer Patients in NTB , Jurnal Biologi Tropis: Vol. 25 No. 4a (2025): Special Issue
Yunan Prabu Jaya Anugrah, Mielosita Hasanah, Romy Healthy Mikailla, Lale Nubya Nitzana, Janiya Abdila Ilmiah, A Systematic Literature Review of The Bronchiectasis , Jurnal Biologi Tropis: Vol. 25 No. 4 (2025): Oktober-Desember

1 2 > >>

Functional Disorders of the Biliary System: Biliary Dyskinesia and Sphincter of Oddi Dysfunction

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow