Phytochemical Profile and Hair Growth Activity of Marigold Flower (Tagetes erecta L.) Extract
DOI:
10.29303/jpm.v21i1.10388Published:
2026-01-23Issue:
Vol. 21 No. 1 (2026): in ProgressKeywords:
Hair Density; Hair Length; Tagetes erecta L.; TLCArticles
Downloads
How to Cite
Downloads
Metrics
Abstract
The Marygold flower (Tagetes erecta L.) exhibits numerous pharmacological properties. The marigold flower promotes hair development. Antioxidant substances that contribute to hair growth include alkaloids, flavonoids, tannins, and saponins. This research was conducted to determine the efficacy of ethanol extracts from Marygold flowers (Tagetes Erecta L.) as hair growers in male rabbits (Oryctolagus cuniculus). In a post-test-only control-group design, this study employed an experimental methodology. Thirty male rabbits served as test subjects in this study, which used one-way ANOVA. The KTL method was used in this study to determine the chemical constituent content of the ethanol extract of Marygold flowers at 5%, 10%, and 20% concentrations. Then, the length and density of the rabbit hair were measured to test the activity of hair growth. On days 7, 14, and 21, hair growth length was measured. On day 21, however, hair weight (density) was measured. Compounds from the flavonoid group (Rf 0.50 & 0.76), tannins (Rf 0.33 & 0.64), saponins (Rf 0.36 & 0.80), and alkaloids (Rf 0.33 & 0.62) were all positively present in the Marygold flower ethanol extract. The 20% concentration of Marygold flower ethanol extract exhibited the highest activity (p<0.05) in tests of hair density and length growth. The ethanol extract from Marygold flowers promotes hair growth in male rabbits, making their hair longer and denser.
References
V. Priskila, “Uji Stabilitas Fisik dan Uji aktivitas Pertumbuhan Rambut Tikus Putih Jantan Dari Sediaan Hair Tonic yang Mengandung Ekstrak Air Bonggol Pisang Kepok (Musa balbisiana),” Skripsi, Fakultas MIPA, Program Studi Farmasi, Universitas Indonesia, Depok, Indonesia, 2012, p. 62.
K. Sayuti and R. Yenrina, Antioksidan Alami dan Sintetik. Padang, Indonesia: Andalas University Press, 2015.
N. Singh and R. Thakur, “A Review on Pharmacological Aspects of Tagetes erecta Linn.,” Pharmacology and Therapeutics, Apr. 2020. doi: 10.29161/PT.v7.i9.2019.16.
P. Aristyanti, “Rendemen dan Karakteristik Ekstrak Pewarna Bunga Kenikir (Tagetes erecta L.) pada Perlakuan Jenis Pelarut dan Lama Ekstraksi,” Jurnal Rekayasa dan Manajemen Agroindustri, vol. 5, no. 3, pp. 13–23, 2017. ISSN 2503-488X.
P. Ingkasupart, B. Manochai, W. T. Song, and J. H. Hong, “Antioxidant Activities and Lutein Content of 11 Marigold Cultivars (Tagetes spp.) Grown in Thailand,” Food Science and Technology Journal, vol. 35, no. 2, pp. 380–385, 2015. doi: 10.1590/1678-457X.6663.
Pramitha, “Aktivitas Antioksidan Bunga Pacar Air Merah (Impatiens balsamina L.) dan Bunga Gemitir (Tagetes erecta L.) dari Limbah Canang,” Chimica et Natura Acta Journal,vol. 6, no. 1, pp. 8–11, 2018. doi: 10.24198/cna.v6.n1.16447
K. R. Kirtikar and B. D. Basu, Tanaman Obat India. Allahabad, India: Lalit Mohan Basu, 1997, vol. 5, pp. 1385–1386.
N. G. Artini and Wartini, “Kandungan Antioksidan Fraksi Air Daun Marigold (Tagetes erecta L.),” Jurnal Widya Kesehatan, vol. 3, no. 2, pp. 25–29, 2021. doi: 10.32795/widyakesehatan.v3i2.2086.
D. Priyanka, T. Shalini, and V. K. Navneet, “A Brief Study on Marigold (Tagetes species): A review,” International Research Journal of Pharmacy, vol. 4, no. 1, pp. 43–48, 2013.
L. Puspitasari and R. W. Desy, “Uji Aktivitas Inhibitor Enzim Tirosinase dan Antioksidan Tagetes erecta L. sebagai Whitening Agent Formulasi Losio Pencerah Kulit,” Jurnal Mandala Pharmacon Indonesia, vol. 8, no. 2, pp. 318–331, 2022. doi: 10.35311/jmpi.v8i2.248.
S. Antoniotti, E. Bassino, F. Gasparri, and L. Munaron, “Effects of Flavonoid Derivatives on Human Microvascular Endothelial Cells,” Natural Product Research Journal, vol. 30, no. 24, pp. 2831–2834, 2016. doi: 10.1080/14786419.2016.1154053
M. Musdalipah and Karmilah, “Efektivitas Ekstrak Daun Cabai Rawit (Capsicum frutescens L.) sebagai Penumbuh Rambut terhadap Hewan Uji Kelinci (Oryctolagus cuniculus),” Riset Ilmu Kesehatan, vol. 7, no. 1, pp. 83–88, 2018. doi: 0.30644/rik.v7i1.137
H. Sigit, “Pengaruh Ekstrak Etanol Daun Mangkokan (Nothopanax scutellarium L.) terhadap Kecepatan Pertumbuhan Rambut Kelinci Jantan dan Profil Kromatogram Lapis Tipisnya,” Skripsi, Fakultas Farmasi, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia, vol. 1, 2005.
Perez, “Tetraoxygenated Naturally Occurring Tannin,” Phytochemistry Journak, vol. 44, no. 2, p. 191, 2000. doi: 10.1016/S0031-9422(00)00303-4.
S. N. Roheni, H. Hervelly, and Irna, “Kajian Konsentrasi Pelarut Terhadap Ekstrak Pigmen dari Sabut Kelapa (Cocos nucifera L.) sebagai Pewarna Alami,” Teknologi Pangan Universitas Pasundan, vol. 1, pp. 1–15, 2020.
R. H. Banu and N. Nagarajan, “TLC and HPTLC Fingerprinting of Leaf Extracts of Wedelia chinensis (Osbeck) Merrill,” Journal of Pharmacognosy and Phytochemistry, vol. 2, no. 6, pp. 29–33, 2014.
M. A. P. Suharto, H. J. Edy, and J. M. Dumanauw, “Isolasi dan Identifikasi Senyawa Saponin dari Ekstrak Metanol Batang Pisang Ambon (Musa paradisiaca var. sapientum L.),” Pharmacon, vol. 1, no. 2, 2012. doi: 10.35799/pha.1.2012.914.
J. Harborne, Metode Fitokimia: Penuntun Cara Modern Menganalisis Tumbuhan. Bandung, Indonesia: ITB Press, 1996.
Q. Aini, “Uji Aktivitas Pertumbuhan Rambut Kelinci Jantan dari Sediaan Hair Tonic yang Mengandung Ekstrak Etanol Daun Mangkokan (Nothopanax scutellarium L.),” JFL: Jurnal Farmasi Lampung, vol. 6, no. 2, pp. 1–12, 2017. doi: 10.37090/jfl.v6i2.16. doi: 10.37090/jfl.v6i2.16.
A. Febriani, “Uji aktivitas dan Keamanan Hair Tonic Ekstrak Daun Kembang Sepatu (Hibiscus rosa-sinensis) pada Pertumbuhan Rambut Kelinci,” Jurnal Farmasi Indonesia, vol. 8, no. 1, pp. 259–269, 2007.
V. Dotulong, L. Montolalu, and T. W. Senduk, “The Rendement of Boiled Water Extract of Mature Leaves of Mangrove Sonneratia alba,” J. Perikan. dan Kelaut. Trop., vol. 11, no. 1, pp. 9–15, 2020. doi: 10.35800/jpkt.11.1.2020.28659.
S. I. Ayu, L. Pratiwi, and S. N. Nurbaeti, “Uji Kualitatif Senyawa Fenol dan Flavonoid dalam Ekstrak N-heksan Daun Senggani (Melastoma malabathricum L.) menggunakan metode kromatografi lapis tipis,” Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, vol. 4, no. 1, pp. 1–6, 2019.
N. Ermawati, “Standardisasi Ekstrak Batang Greges Otot (Equisetum debile Roxb.),” Pena Medika Jurnal Kesehatan, vol. 9, no. 2, pp. 15–25, 2019. doi: 10.31941/pmjk.v9i2.934
G. Cotsarelis and V. St. Botchkarev, Biology of Hair Follicles in Fitzpatrick’s Dermatology in General Medicine. McGraw-Hill, 2008.
L. Soepardiman and L. Legiawati, “Kelainan Rambut,” in Buku Ilmu Penyakit Kulit dan Kelamin, E. Menaldi, Ed., 7th ed. Jakarta, Indonesia: Badan Penerbit FK UI, 2018, pp. 359–364.
P. Indrayoni and A. A. I. Padmiswari, “Potensi Ekstrak Hibiscus rosa-sinensis L. dan Baccaurea racemosa sebagai Pertumbuhan Rambut dengan Tail Suspension test,” Jurnal Ilmu Farmasi Ad-Dawaa, vol. 5, no. 1, pp. 1–7, 2022. doi: 10.24252/djps.v5i1.27645.
A. Rook and R. Dawber, Diseases of the Hair and Scalp, 2nd ed. Oxford, U.K.: Blackwell Scientific, 1991.
R. A. Hiipakka, H. Z. Zhang, W. Dai, Q. Dai, and S. Liao, “Structure–Activity Relationships for Inhibition of Human 5α-reductases by Polyphenols,” Biochemical Pharmacology Journal, vol. 63, pp. 1165–1176, 2002. doi: 10.1016/S0006-2952(02)00848-1.
Author Biographies
Lia Puspitasari, Pharmacology Department, Faculty of Medicine, Udayana University
Putu Indrayoni, Community and Clinical Pharmacy Study Program, Faculty of Health, Institute of Technology and Health Bali
Putu Ayudia Septiarini, Community and Clinical Pharmacy Study Program, Faculty of Health, Institute of Technology and Health Bali
License
Copyright (c) 2026 Lia Puspitasari, Putu Indrayoni, Putu Ayudia Septiarini
This work is licensed under a Creative Commons Attribution 4.0 International License.
The following terms apply to authors who publish in this journal:
1. Authors retain copyright and grant the journal first publication rights, with the work simultaneously licensed under a Creative Commons Attribution License 4.0 International License (CC-BY License) that allows others to share the work with an acknowledgment of the work's authorship and first publication in this journal.
2. Authors may enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., posting it to an institutional repository or publishing it in a book), acknowledging its initial publication in this journal.
3. Before and during the submission process, authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website), as this can lead to productive exchanges as well as earlier and greater citation of published work (See The Effect of Open Access).
